cefsulodin and Meningitis

Four neonates and young infants were treated with cefsulodin (CFS) at doses ranging from 20-25 mg/kg every 6 hours for 6.25 to 17 days, and clinical efficacy and side effects were evaluated. Among the 4 infants with bacterial infections including meningitis, bronchitis and pneumonia, the results were good in 2 patients with meningitis, but unknown in 2 patients because of additional use of gentamicin. One of the 4 patients had eosinophilia. Minimal inhibitory concentrations of CFS against 4 isolates of Pseudomonas aeruginosa were 1.56 against one and 12.5 micrograms/ml against other 3 strains with an inoculum size of 10(3) CFU. Serum concentrations of CFS were measured in one- and four-month-old infants upon 25.3 and 20.9 mg/kg bolus intravenous injection of the antibiotic, respectively. The values were 36.4 and 33.4 at 30 minutes, and 5.1 and 3.2 micrograms/ml at 6 hours after injection, respectively. Serum half-lives were 1.89 and 1.69 hours, respectively. Total body clearances and volume distributions were 3.16 and 3.76 ml/min/kg, and 519.0 and 551.2 ml/kg, respectively.

Topics: Bronchitis; Cefsulodin; Drug Evaluation; Female; Humans; Infant; Infant, Newborn; Male; Meningitis; Pneumonia; Pseudomonas aeruginosa; Staphylococcus aureus

Experimental meningitis was induced in rats with Pseudomonas aeruginosa. Bacteria were inoculated in the second ventricle. Twenty hours later cefsulodin penetration was studied in CSF by on-line cannula system which permitted sampling of CSF in the third ventricle. Comparison with healthy animals indicated breakdown of the blood-CSF barrier and high concentrations of cefsulodin were found in CSF.

Topics: Animals; Cefsulodin; Male; Meningitis; Pseudomonas Infections; Rats; Rats, Inbred Strains

The article reports on the incidence, the conditions of occurrence, possibilities and successes of treatment with certain (combinations of) antibiotics, in dealing with cases of pseudomonas meningitis. The various possible substances used for treatment are discussed. Rates of penetration and CSF concentrations of azlocillin and cefsulodin are stated. Alternative possibilities for treatment are pointed out.

Topics: Aminoglycosides; Anti-Bacterial Agents; Azlocillin; Bacteriological Techniques; Brain Injuries; Cefsulodin; Cephalosporins; Diagnosis, Differential; Fosfomycin; Humans; Meningitis; Penicillins; Polymyxins; Pseudomonas Infections

Topics: Age Factors; Animals; Cefsulodin; Cephalosporins; Child; Child, Preschool; Drug Resistance, Microbial; Female; Humans; Infant; Infant, Newborn; Male; Meningitis; Pseudomonas aeruginosa; Rabbits