cefroxadine has been researched along with Kidney-Diseases* in 2 studies
2 other study(ies) available for cefroxadine and Kidney-Diseases
Article | Year |
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Relationship between pharmacokinetics and bioavailability of cefroxadine (CGP 9000) and renal function.
The pharmacokinetics and bioavailability of cefroxadine were studied in 15 patients with different renal functions after administration of 0.5 g as oral capsules and as intravenous infusions. Microbiological assays by agar diffusion and high-pressure liquid chromatography may both be used for this agent since no metabolite can be found. The bioavailability is near 100% of the oral dose regardless of renal function. Urinary recovery varied from about 50% in renal glomerular filtration rates (GFR) of less than 7 ml/min to nearly 100% in normal renal function. The serum concentrations, serum elimination half-life and total body clearance were significantly influenced by reduced renal function. Nonrenal elimination occurred in reduced renal function; the maximum serum elimination half-life was 24.6 h. Dose modifications according to renal function are suggested with from three doses/24 in normal renal function to one dose/24 h in patients with GFR of 10 ml/min. The relative distribution volume corresponded to approximately 30% of the body weight. Tubular secretion of cefroxadine took place. The concentrations in urine remained above 32 mg/l for 12 h in all subjects regardless of renal function. Topics: Adult; Aged; Biological Assay; Biological Availability; Cephalosporins; Cephradine; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Kidney Diseases; Kinetics; Male; Middle Aged | 1983 |
Pharmacokinetics of cefroxadine in healthy volunteers and patients with impaired renal function.
The pharmacokinetics of cefroxadine, a new orally active broad-spectrum cephalosporin, was studied in healthy volunteers and patients with impaired renal function after a single oral dose of 500 mg. The pharmacokinetic parameters of cefroxadine were obtained by analysing the serum level data of the drug based on a one-compartment open model. The mean serum half-life of cefroxadine was 0.97 h in healthy subjects, and was prolonged to 41.7 h in patients with a creatinine clearance of less than 5 ml/min. There was a significant linear correlation (p less than 0.001) between the elimination rate constant of the drug and the creatinine clearance. In healthy subjects, 71% of the administered dose was excreted in the urine collected over the first 6 h. Topics: Adult; Aged; Cephalosporins; Cephradine; Creatinine; Humans; Kidney Diseases; Kinetics; Middle Aged | 1981 |