cefquinome and Gram-Positive-Bacterial-Infections

Chemotherapy as a science began within the 1st decade of the twentieth century with understanding of the principles of selective toxicity, the particular chemical relationships between microorganism pathogens and medicines, the event of drug resistance, and also the role of combined medical aid.. This review aims to highlight the characteristics, specifically the pharmacokinetic parameters and the analytical methods reported in literature for the determination of Cefquinome, a fourth generation cephalosporine used to treat Gram-positive and Gram-negative caused infections.. Analysis of such drugs, whether used for the treatment of human or animal illness, is essential in understanding the bioavailability and therapeutic control which will ensure their activity and safety.

Topics: Animals; Anti-Bacterial Agents; Biological Availability; Cephalosporins; Drug Resistance, Bacterial; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Humans; Molecular Structure; Veterinary Drugs

Cefquinome is the first 4th generation cephalosporin antibiotic developed for use in veterinary medicine. A European multicentre study established a high in vitro activity for this modern antimicrobial drug against a wide spectrum of bovine pathogens. Gram-positive and gram-negative mastitis agents were inactivated even at very low active ingredient concentrations, including Enterobacteriaceae which are often resistant to other drugs. The results of clinical trials using experimental E. coli mastitis as an example demonstrate the efficacy of cefquinome in vivo. Parenteral administration at a dose rate of 1 mg/kg body weight when compared with conventional therapy using a control drug with equally good in vitro activity, produced significantly better therapeutic results.

Topics: Animals; Cattle; Cephalosporins; Clinical Trials as Topic; Enterobacteriaceae Infections; Escherichia coli Infections; Female; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Mastitis, Bovine; Multicenter Studies as Topic