cefpodoxime-proxetil and Endocarditis--Bacterial

Infective endocarditis (IE) is uncommon in children, affecting predominantly subjects with congenital heart disease (CHD) and patients with indwelling central lines. The principles of antibiotic treatment in paediatric population are similar to those in adults. Prolonged intravenous administration of bactericidal rather than bacteriostatic agents is preferred. Outpatient intravenous therapy after initial treatment in the hospital may be considered only in selected patients. Partial oral treatment has been described in cases of left-sided, uncomplicated IE caused by common pathogens in adult patients. There are no guidelines or trials in paediatric population regarding switching therapy from intravenous to oral route. We present two cases of IE in children caused by uncommon pathogenic bacteria (

Topics: Abiotrophia; Administration, Intravenous; Administration, Oral; Anti-Bacterial Agents; Cefpodoxime Proxetil; Ceftizoxime; Child; Child, Preschool; Endocarditis, Bacterial; Female; Gram-Positive Bacterial Infections; Haemophilus Infections; Humans; Male