cefpiramide and Skin-Diseases--Infectious

cefpiramide has been researched along with Skin-Diseases--Infectious* in 2 studies

Other Studies

2 other study(ies) available for cefpiramide and Skin-Diseases--Infectious

Article	Year
[The penetration of cefpiramide into the skin]. The Japanese journal of antibiotics, 1992, Volume: 45, Issue:10 To investigate the skin penetration of cefpiramide (CPM, SM-1652), a broad-spectrum and long acting cephem antibiotic, 1 g of CPM was administered by single bolus intravenous injection to patients under general anesthesia during operations for full-thickness skin grafting. The CPM levels in both the serum and the skin were determined by bioassay at specified time intervals, and the following results were obtained. 1. Peak CPM concentrations in the serum (mean: 292.78 micrograms/ml) were observed 10 minutes after administration, and declined very slowly thereafter. 2. Peak CPM concentrations in the skin (mean: 23.05 micrograms/g) were observed 2 hours after administration, and then also declined very slowly. 3. The ratio of skin to serum concentrations was 16% when the peak CPM concentrations in the skin were obtained (2 hours after the administration). These results show that effective CPM concentrations were maintained in the skin for a long period, indicating a good therapeutic action against skin infections. Topics: Adult; Cephalosporins; Humans; Injections, Intravenous; Skin; Skin Diseases, Infectious; Skin Transplantation	1992
[Clinical effect of intramuscular injection of cefpiramide in infections associated with surgery]. The Japanese journal of antibiotics, 1983, Volume: 36, Issue:8 The authors treated a total of 23 patients (15 were outpatients, 8 were hospitalized), employing an injectable preparation of cefpiramide (CPM) a new antibiotic of the cephems. Included in this total were 10 cases of acute infectious diseases of skin and soft tissues, 5 cases of acute localized peritonitis, 5 cases of acute urinary tract infection and 3 cases of acute and subacute cholecystitis. To 15 cases of outpatients, CPM in a dose of 500 mg were given by intramuscular injection once a day, and to 8 cases of hospitalized patients were given 500 mg of CPM by intramuscular injection twice a day. The duration were 3 to 15 days. The clinical efficacy obtained was excellent in 4 cases, good in 17 cases, and fair in 2 cases. In no case was CPM found to be completely ineffective. Clinical adverse effect was not recognized. Therefore, CPM will be a useful drug when used for chemotherapy of acute or subacute infectious diseases on surgical field following intramuscular administration. Topics: Acute Disease; Adult; Aged; Bacterial Infections; Cephalosporins; Cholecystitis; Drug Evaluation; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Peritonitis; Postoperative Complications; Skin Diseases, Infectious; Urinary Tract Infections	1983

Article

Year

[The penetration of cefpiramide into the skin].

The Japanese journal of antibiotics, 1992, Volume: 45, Issue:10

To investigate the skin penetration of cefpiramide (CPM, SM-1652), a broad-spectrum and long acting cephem antibiotic, 1 g of CPM was administered by single bolus intravenous injection to patients under general anesthesia during operations for full-thickness skin grafting. The CPM levels in both the serum and the skin were determined by bioassay at specified time intervals, and the following results were obtained. 1. Peak CPM concentrations in the serum (mean: 292.78 micrograms/ml) were observed 10 minutes after administration, and declined very slowly thereafter. 2. Peak CPM concentrations in the skin (mean: 23.05 micrograms/g) were observed 2 hours after administration, and then also declined very slowly. 3. The ratio of skin to serum concentrations was 16% when the peak CPM concentrations in the skin were obtained (2 hours after the administration). These results show that effective CPM concentrations were maintained in the skin for a long period, indicating a good therapeutic action against skin infections.

Topics: Adult; Cephalosporins; Humans; Injections, Intravenous; Skin; Skin Diseases, Infectious; Skin Transplantation

1992

[Clinical effect of intramuscular injection of cefpiramide in infections associated with surgery].

The Japanese journal of antibiotics, 1983, Volume: 36, Issue:8

The authors treated a total of 23 patients (15 were outpatients, 8 were hospitalized), employing an injectable preparation of cefpiramide (CPM) a new antibiotic of the cephems. Included in this total were 10 cases of acute infectious diseases of skin and soft tissues, 5 cases of acute localized peritonitis, 5 cases of acute urinary tract infection and 3 cases of acute and subacute cholecystitis. To 15 cases of outpatients, CPM in a dose of 500 mg were given by intramuscular injection once a day, and to 8 cases of hospitalized patients were given 500 mg of CPM by intramuscular injection twice a day. The duration were 3 to 15 days. The clinical efficacy obtained was excellent in 4 cases, good in 17 cases, and fair in 2 cases. In no case was CPM found to be completely ineffective. Clinical adverse effect was not recognized. Therefore, CPM will be a useful drug when used for chemotherapy of acute or subacute infectious diseases on surgical field following intramuscular administration.

Topics: Acute Disease; Adult; Aged; Bacterial Infections; Cephalosporins; Cholecystitis; Drug Evaluation; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Peritonitis; Postoperative Complications; Skin Diseases, Infectious; Urinary Tract Infections

1983