cefpiramide and Enteritis

Twenty-one pediatric patients with moderate or severe infections were treated with cefpiramide (CPM). The drug was given intravenously in a dose of 10 approximately 52.3 mg per kg at 8 approximately 12 hourly interval. All 7 patients with urinary tract infection, 4 with bacterial enteritis and 4 out of 7 patients with lower respiratory tract infections responded satisfactory, but 2 patients with either Serratia marcescens septicemia or H. influenzae meningitis not responded to treatment. Over all response rate was 71.4 percent. There was no change in test of liver and renal function. CPM appears to be effective and well-tolerated antibiotics for the treatment of pediatric patients with various infections.

Topics: Age Factors; Bacterial Infections; Cephalosporins; Child; Child, Preschool; Drug Evaluation; Enteritis; Female; Humans; Infant; Injections, Intravenous; Male; Respiratory Tract Infections; Urinary Tract Infections

Clinical studies of cefpiramide (CPM), a newly developed cephem antibiotic, were performed in 10 children with respiratory tract infection in 4 cases, acute enteritis in 2 cases and urinary tract infection in 4 cases aged from 2 months to 10 years and 4 months. CPM was intravenously given to patients at doses of 16 approximately 58 mg/kg/day divided into 3 times for 3 approximately 22 days. Clinical effects were excellent in 6, good in 3 and fair in 1. Bacteriologically, 3 strains of pathogenic organisms (Salmonella C2 group, E. coli and S. faecalis) isolated from the patients were eradicated with the treatment of CPM. No side effect was observed.

Topics: Age Factors; Bacteria; Cephalosporins; Child; Child, Preschool; Drug Evaluation; Drug Resistance, Microbial; Enteritis; Female; Humans; Infant; Male; Respiratory Tract Infections; Urinary Tract Infections