cefpiramide and Endometritis

Cefpiramide (SM-1652, CPM), a new cephem antibiotic was studied for the transfer into intrapelvic tissues and clinical efficacy in the field of obstetrics and gynecology. The results were obtained as follows. Clinical results of 17 patients with obstetrical and gynecological infection were excellent in 10 cases, good in 6, and poor in 1 with the efficacy rate of 94.1%. Following a single intravenous 30 minutes-drip infusion of 1 g dose of CPM, the peak of serum level and intrapelvic tissues were obtained at 30-60 minutes after completion of the administration. No adverse reaction or abnormal laboratory findings were observed.

Topics: Adult; Aged; Bacterial Infections; Cephalosporins; Drug Resistance, Microbial; Endometritis; Escherichia coli; Female; Genital Diseases, Female; Humans; Kinetics; Middle Aged; Pregnancy; Puerperal Infection; Uterus

Cefpiramide (CPM) was administrated intramuscularly to 27 cases of gynecological infections to evaluate its clinical efficacy and safety and the following results wee obtained. CPM was effective to all the cases of gynecological infections, and excellent was seen in 14 cases and good was seen in 13 cases. CPM eliminated 75% of clinical isolates. Laboratory tests were performed to blood samples and functions of liver and kidney before and after CPM treatment. Elevation of GPT was observed in 2 cases but required no treatment.

Topics: Adolescent; Adult; Bacteria, Anaerobic; Bacterial Infections; Cephalosporins; Drug Evaluation; Drug Resistance, Microbial; Endometritis; Female; Genital Diseases, Female; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Middle Aged; Pelvic Inflammatory Disease