cefoxitin and Thrombophlebitis

Topics: Adolescent; Arthritis, Infectious; Bacteremia; Cefoxitin; Clindamycin; Fusobacterium Infections; Fusobacterium necrophorum; Humans; Jugular Veins; Male; Metronidazole; Peritonsillar Abscess; Pharyngitis; Syndrome; Thrombophlebitis

In order to evaluate the efficacy of cefoxitin, 25 patients with serious pelvic infections admitted to a community hospital were treated with the drug. Twenty-one patients (84%) responded to this therapy. Three of the four failures (75%) had a pelvic abscess. Resistant organisms included Staphylococcus aureus, Pseudomonas aeruginosa and enterococci. The adverse reactions encountered were due to localized phlebitis, which occurred in three patients (12%). The study demonstrated that cefoxitin was successful as a single agent in the treatment of serious soft-tissue pelvic infections.

Topics: Adult; Bacterial Infections; Cefoxitin; Drug Evaluation; Drug Resistance, Microbial; Female; Humans; Infusions, Intravenous; Length of Stay; Microbial Sensitivity Tests; Middle Aged; Pelvic Inflammatory Disease; Thrombophlebitis; Treatment Failure

Side effects of cefoxitin and cefuroxime were noted in 2 different studies during intravenous treatment for at least 14 days. In the cefoxitin group of 33 patients thrombophlebitis was observed in 3 cases and diarrhoea in 4 cases. In the cefuroxime group of 31 patients 1 case of thrombophlebitis was noted and 5 cases of diarrhoea occurred. Most patients with diarrhoea had decreased renal function or received higher dosage of the antibodies than the other patients.

Topics: Aged; Cefoxitin; Cefuroxime; Cephalosporins; Diarrhea; Glomerular Filtration Rate; Half-Life; Humans; Injections, Intravenous; Thrombophlebitis