cefoxitin and Shock

cefoxitin has been researched along with Shock* in 2 studies

Other Studies

2 other study(ies) available for cefoxitin and Shock

Article	Year
Severe bleeding in postoperative patients with infections. The Annals of pharmacotherapy, 1994, Volume: 28, Issue:11 Topics: Aged; Ampicillin; Blood Platelet Disorders; Cefoxitin; Hematoma; Hemoperitoneum; Humans; Male; Postoperative Complications; Shock; Surgical Wound Infection	1994
Interferon gamma and tumor necrosis factor alpha. Use in gram-negative infection after shock. Archives of surgery (Chicago, Ill. : 1960), 1990, Volume: 125, Issue:4 Shock increases the propensity to develop infection after injury or operation. This study evaluated the effect of cefoxitin, interferon gamma (INF-gamma), and tumor necrosis factor alpha (TNF-alpha) on the development of a polymicrobial soft-tissue infection. After sham operation or hemorrhagic shock and resuscitation, Sprague-Dawley rats were inoculated with 1 x 10(8) Escherichia coli and 1 x 10(9) Bacteroides fragilis in a 5% fecal suspension. Animals received either no treatment, cefoxitin, recombinant rat INF-gamma, recombinant human TNF-alpha, or cefoxitin/cytokine combinations. Cefoxitin reduced abscess size by 57% in animals without shock but only by 26% after shock. Although neither INF-gamma nor TNF-alpha alone had a salutary effect when given with cefoxitin in animals after shock, INF-gamma and TNF-alpha reduced abscess size by 50% and 55%, respectively. These results suggest that INF-gamma and TNF-alpha may be useful to reduce the severity of mixed gram-negative infections after shock with bacterial contamination. Topics: Abscess; Animals; Cefoxitin; Escherichia coli Infections; Female; Interferon-gamma; Rats; Rats, Inbred Strains; Recombinant Proteins; Shock; Tumor Necrosis Factor-alpha	1990

Article

Year

Severe bleeding in postoperative patients with infections.

The Annals of pharmacotherapy, 1994, Volume: 28, Issue:11

Topics: Aged; Ampicillin; Blood Platelet Disorders; Cefoxitin; Hematoma; Hemoperitoneum; Humans; Male; Postoperative Complications; Shock; Surgical Wound Infection

1994

Interferon gamma and tumor necrosis factor alpha. Use in gram-negative infection after shock.

Archives of surgery (Chicago, Ill. : 1960), 1990, Volume: 125, Issue:4

Shock increases the propensity to develop infection after injury or operation. This study evaluated the effect of cefoxitin, interferon gamma (INF-gamma), and tumor necrosis factor alpha (TNF-alpha) on the development of a polymicrobial soft-tissue infection. After sham operation or hemorrhagic shock and resuscitation, Sprague-Dawley rats were inoculated with 1 x 10(8) Escherichia coli and 1 x 10(9) Bacteroides fragilis in a 5% fecal suspension. Animals received either no treatment, cefoxitin, recombinant rat INF-gamma, recombinant human TNF-alpha, or cefoxitin/cytokine combinations. Cefoxitin reduced abscess size by 57% in animals without shock but only by 26% after shock. Although neither INF-gamma nor TNF-alpha alone had a salutary effect when given with cefoxitin in animals after shock, INF-gamma and TNF-alpha reduced abscess size by 50% and 55%, respectively. These results suggest that INF-gamma and TNF-alpha may be useful to reduce the severity of mixed gram-negative infections after shock with bacterial contamination.

Topics: Abscess; Animals; Cefoxitin; Escherichia coli Infections; Female; Interferon-gamma; Rats; Rats, Inbred Strains; Recombinant Proteins; Shock; Tumor Necrosis Factor-alpha

1990