cefoxitin and Puerperal-Disorders

The purpose of this study was to determine the effect of intrapartum prophylactic antibiotics in the prevention of postpartum sepsis in laboring women who were infected with HIV.. In a double-blind, randomized trial that was conducted in Durban (South Africa), pregnant women who were infected with HIV in whom vaginal delivery was anticipated were randomized to receive either a single dose of cefoxitin (2 g) or placebo intrapartum. Signs of sepsis were evaluated within 72 hours and at 1 and 2 weeks postpartum.. Of the 424 women who were enrolled, 213 women received cefoxitin, and 211 women received placebo. Both groups were comparable in all baseline parameters. The overall sepsis rate was 19% (40/211 women) in the placebo group and 16.9% (36/213 women) in the cefoxitin group (P = .581). There was a 53% reduction in risk of postpartum endometritis in the cefoxitin group (95% confidence interval, 0.24-0.9).. The use of prophylactic intrapartum cefoxitin in HIV-infected women reduces the risk of postpartum endometritis.

Topics: Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cefoxitin; Double-Blind Method; Drug Administration Schedule; Endometritis; Female; HIV Infections; Humans; Incidence; Pregnancy; Pregnancy Complications, Infectious; Puerperal Disorders; South Africa