cefoxitin and Pleuropneumonia

Two models of pneumonia--the experimental E. coli-pleuropneumonia and "intrapulmonary" E. coli-pneumonia--were employed in these studies. Only fosfomycin was effective in both models even at the low dosage of 100 mg/kg/d. The comparative drugs cefotaxime and cefoxitin, however, were not able to reduce the bacteria in both lungs even at very high dosages of 900 mg/kg and 300 mg/kg per day respectively over 6 days.

Topics: Animals; Anti-Bacterial Agents; Cefotaxime; Cefoxitin; Cephalosporins; Dose-Response Relationship, Drug; Escherichia coli Infections; Female; Fosfomycin; Kinetics; Pleuropneumonia; Rats