cefoxitin and Otitis-Media

Mycobacterium fortuitum is a rarely reported cause of otitis media and mastoiditis. We report such a case recently seen at our institution and review the four previously published cases of this disease entity. Amikacin is recommended in the current medical literature as empirical treatment of disease due to M. fortuitum, but the isolate from our patient showed high-level resistance to amikacin, which is rare in clinical isolates of this species; this resistance was probably related to prior treatment with topical aminoglycosides. Our patient's infection responded to a 12-month course of therapy with clarithromycin and trimethoprim-sulfamethoxazole.

Topics: Adolescent; Amikacin; Anti-Bacterial Agents; Cefoxitin; Clarithromycin; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Humans; Mastoiditis; Mycobacterium Infections; Nontuberculous Mycobacteria; Otitis Media; Trimethoprim, Sulfamethoxazole Drug Combination

After having described the method of application used for iontophoresis and the results of previous studies carried out by other authors in the hope of finding a definite use for its clinical application, the authors present their personal experience carried out with the use of various chemical substances applied to both the guinea pig and to man. The chemicals taken into consideration were those used in the treatment of otitis media: anti-inflammatory, antibiotic, and mucolytic products. Iontophoresis proved to be a simple and effective method for the treatment of certain middle ear diseases, and offered a more rapid recovery in comparison with subjects treated uniquely by traditional methods.

Topics: Acetylcysteine; Animals; Benzydamine; Cefoxitin; Child; Electrodes; Guinea Pigs; Humans; Iontophoresis; Otitis Media; Pyrazoles; Tympanic Membrane