cefoxitin and Hyperoxia

International studies could already prove a correlation between alexithymia and expressive suppression. This relationship has only been marginally considered in the German literature so far. The prioritized aim of the present study was to investigate a correlative and factorial relationship between alexithymia and expressive suppression.. A total of 317 persons participated in an online survey. Data on alexithymia and expressive suppression were collected using the German versions of the Toronto alexithymia scale (TAS-26) and the emotion regulation questionnaire (ERQ).. The results indicate that the TAS-26 scales in the components "difficulty in identifying feelings" and "difficulty in describing feelings" and the ERQ scale "suppression" in the component of "expressive suppression" have a common construct, which is referred to with the term speechlessness.. The online version contains supplementary material available at 10.1186/s40623-021-01518-w.. Even though the present study confirmed expected differences in complications and morbidity, it suggested that oncoplastic surgery is oncologically safe. Patients undergoing NSM/SSM should be followed closely to allow early detection and treatment of frequently associated complications and ensure timely start of adjuvant therapy.

Topics: Acacia; Acute Disease; Adaptive Immunity; Adolescent; Adult; Aged; Aged, 80 and over; Animals; Animals, Newborn; Anti-Bacterial Agents; Antibodies, Monoclonal; Antigens, Tumor-Associated, Carbohydrate; Biofilms; Biomarkers; Child; Child, Preschool; CRISPR-Cas Systems; Cytokines; Escherichia coli; Female; Gene Expression Profiling; Gene Knockout Techniques; Humans; Hypercalcemia; Hyperoxia; I-kappa B Kinase; Immunity, Cellular; Infant; Infant, Newborn; Inflammation; Interleukin-1 Receptor-Like 1 Protein; Interleukin-13; Kidney; Macrophage Activation; Macrophages; Male; Membrane Transport Modulators; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Middle Aged; Mutation; NF-kappa B p50 Subunit; Oxidative Stress; Pancreatitis; Phenotype; Plant Bark; Plant Extracts; Plant Stems; RNA-Seq; Severity of Illness Index; Sodium-Phosphate Cotransporter Proteins, Type IIa; Sodium-Phosphate Cotransporter Proteins, Type IIc; Staphylococcus aureus; THP-1 Cells; Toll-Like Receptors; Transcription Factor RelA; Transcriptome; Vitamin D3 24-Hydroxylase; Young Adult

Neonatal hyperoxia increases oxidative stress and adversely disturbs glomerular and tubular maturity. Maternal Tn immunization induces anti-Tn antibody titer and attenuates hyperoxia-induced lung injury in neonatal rats.. We intraperitoneally immunized female Sprague-Dawley rats (6 weeks old) with Tn immunogen (50 μg/dose) or carrier protein five times at biweekly intervals on 8, 6, 4, 2, and 0 weeks before the delivery day. The pups were reared for 2 weeks in either room air (RA) or in 85% oxygen-enriched atmosphere (O. Hyperoxia reduced body weight, induced tubular and glomerular injuries, and increased 8-OHdG and NF-κB expression and collagen deposition in the kidneys. By contrast, maternal Tn immunization reduced kidney injury and collagen deposition in neonatal rats. Furthermore, kidney injury attenuation was accompanied by a reduction in 8-OHdG and NF-κB expression.. Maternal Tn immunization protects against hyperoxia-induced kidney injury in neonatal rats by attenuating oxidative stress and NF-κB activity.. Hyperoxia increased nuclear factor-κB (NF-κB) activity and collagen deposition in neonatal rat kidney. Maternal Tn immunization reduced kidney injury as well as collagen deposition in neonatal rats. Maternal Tn immunization reduced kidney injury and was associated with a reduction in 8-hydroxy-2'-deoxyguanosine and NF-κB activity. Tn vaccine can be a promising treatment modality against hyperoxia-induced kidney injury in neonates.

Topics: Acute Kidney Injury; Animals; Animals, Newborn; Antigens, Tumor-Associated, Carbohydrate; Body Weight; Collagen; Deoxyadenosines; Female; Hyperoxia; Immunotherapy, Active; Kidney Tubules; NF-kappa B; Organ Size; Oxidative Stress; Pregnancy; Random Allocation; Rats; Rats, Sprague-Dawley; Vaccination; Vacuoles

Hyperoxia therapy is often required to treat newborns with respiratory disorders. Prolonged hyperoxia exposure increases oxidative stress and arrests alveolar development in newborn rats. Tn antigen is N-acetylgalactosamine residue that is one of the most remarkable tumor-associated carbohydrate antigens. Tn immunization increases the serum anti-Tn antibody titers and attenuates hyperoxia-induced lung injury in adult mice. We hypothesized that maternal Tn immunizations would attenuate hyperoxia-induced lung injury through the suppression of oxidative stress in neonatal rats. Female Sprague-Dawley rats (6 weeks old) were intraperitoneally immunized five times with Tn (50 μg/dose) or carrier protein at biweekly intervals on 8, 6, 4, 2, and 0 weeks before the day of delivery. The pups were reared in room air (RA) or 2 weeks of 85% O

Topics: Animals; Animals, Newborn; Antibodies; Antigens, Tumor-Associated, Carbohydrate; Biomarkers; Cytokines; Disease Models, Animal; Female; Hyperoxia; Immunization; Immunohistochemistry; Inflammation; Lung Injury; Macrophages, Alveolar; Maternal Exposure; Oxidative Stress; Rats

Prolonged hyperoxia exposure leads to inflammation and acute lung injury. Since hyperoxia activates nuclear factor kappa B (NF-κB) and proinflammatory mediators in lung fibroblasts and murine lungs, and proinflammatory cytokines upregulate Tn (N-acetyl-d-galactosamine-O-serine/threonine) expression in human gingival fibroblasts. We hypothesized connections exist between Tn expression and inflammation regulation. Thus, we immunized adult mice with Tn antigen to examine whether Tn vaccine can protect against hyperoxia-induced lung injury by inhibiting NF-κB activity and cytokine expression through the action of anti-Tn antibodies. Five-week-old female C57BL/6NCrlBltw mice were subcutaneously immunized with Tn antigen four times at biweekly intervals, and one additional immunization was performed at 1 week after the fourth immunization. Four days after the last immunization, mice were exposed to room air (RA) or hyperoxia (100% O

Topics: Acute Lung Injury; Animals; Antibodies; Antigens, Tumor-Associated, Carbohydrate; Bronchoalveolar Lavage Fluid; Cytokines; Female; Hyperoxia; Immunization; Interleukin-6; Lung; Macrophages, Alveolar; Mice; Mice, Inbred C57BL; NF-kappa B; Tumor Necrosis Factor-alpha