cefoxitin and Connective-Tissue-Diseases

In a randomized comparative trial, 45 patients were treated with amdinocillin plus cefoxitin or cefoxitin alone for bacterial soft tissue infections. Most patients were diabetic and had polymicrobial foot infections. The combination of amdinocillin plus cefoxitin was active in vitro against 71 percent of the isolates obtained before therapy as compared with 65 percent for cefoxitin alone. The combination demonstrated synergy for 29 percent of the isolates tested. A satisfactory clinical response occurred in 90 percent and 71 percent of patients treated with the combination regimen and cefoxitin, respectively, (p greater than 0.1). An increase in serum creatinine thought to be due to interstitial nephritis occurred in one patient treated with the combination regimen. The combination of amdinocillin and cefoxitin was effective in mixed soft tissue infections including diabetic foot infections.

Topics: Adult; Aged; Amdinocillin; Bacterial Infections; Cefoxitin; Connective Tissue Diseases; Diabetes Complications; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Injections, Intravenous; Male; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Random Allocation

Mycobacterium fortuitum is an environmental organism which rarely causes disease. We report the case of a young man in whom this organism caused a soft tissue abscess. The laboratory findings and subsequent management of the case are described.

Topics: Abscess; Adult; Cefoxitin; Ciprofloxacin; Connective Tissue Diseases; Humans; Male; Mycobacterium Infections