cefoxitin and Cholelithiasis

The bile levels of cefoxitin and cefamandole were studied in 75 patients. The two antibiotics were shown to be present at high concentration and to undergo a rapid metabolization. It is concluded that they represent the antibiotics of choice in the prophylactic and therapeutic treatment of biliary tract infections.

Topics: Bile; Bile Duct Diseases; Cefamandole; Cefoxitin; Cholelithiasis; Chromatography, High Pressure Liquid; Humans; Microbial Sensitivity Tests; Sarcina

A total of 16 hospitalized patients underwent surgery for gastroenterological problems in the Department of Gastroenterological Surgery, Kanazawa Medical College Hospital, during the period from April 1981 to September 1981. After they had undergone partial or total gastroenterological resection, cefoxitin was administered for the prevention of postoperative infections. The following findings were obtained. 1. Fifteen out of 16 patients responded well with the clinical efficacy of 94 percent. 2. Elevations in S-GOT levels were noted in 3 patients. However, no other abnormalities were evident in the clinical data. 3. These clinical results indicate that cefoxitin is an effective antibiotic for the prevention of postoperative infections in gastroenterological surgery.

Topics: Adult; Aged; Bacterial Infections; Cefoxitin; Cholelithiasis; Female; Gastrectomy; Humans; Male; Middle Aged; Postoperative Complications; Stomach Neoplasms; Surgical Wound Infection