cefmenoxime and Postoperative-Complications

Cefmenoxime (CMX) at a dose of 1 g was administered intravenously to each of 10 patients undergoing thoracotomy, and concentrations of CMX in the serum and pleural fluid were measured. Serum concentration of CMX reached its peak of 43.71 micrograms/ml at 1 hour and decreased to 4.15 micrograms/ml at 3 hours after the administration. The concentration of CMX in the pleural fluid reached its peak of 7.61 micrograms/ml at 3 hours and decreased slowly 5.26 micrograms/ml at 7 hours after the administration. A clinical study with 21 patients was performed to evaluate the effect of CMX as a prophylactic antimicrobial agent in thoracotomy. Patients received intravenous administration of 4 g/day of CMX for 7-10 days following operations. Each patient was evaluated daily for fever, sign of allergic reaction, and wound infection and other symptoms. No apparent infection occurred in those clinical patients except 1 patient with a suspected infection, and 1 case of allergic reaction as exanthema was observed during this study. Prophylactic effect of CMX against postoperative infection after thoracotomy was good.

Topics: Adult; Aged; Bacterial Infections; Cefmenoxime; Cefotaxime; Drug Evaluation; Female; Humans; Lung Neoplasms; Male; Middle Aged; Pleural Effusion; Pneumothorax; Postoperative Complications; Premedication; Thoracic Surgery

Twenty patients who were performed pulmonary resection for the disease of the lung were administered 2 g of cefmenoxime (CMX) intravenously during the operation. The CMX levels in serum, lung tissue and thoracic muscle were measured by agar-well technique. The CMX levels in lung tissue and thoracic muscle were higher than the MIC80 of CMX for Klebsiella pneumoniae, Haemophilus influenzae and Streptococcus pneumoniae which were commonly as isolated causative organisms from the patients with pulmonary infection. These results indicate that CMX will be useful agent for the prevention and treatment of pulmonary infection.

Topics: Adolescent; Adult; Aged; Bacterial Infections; Cefmenoxime; Cefotaxime; Female; Humans; Injections, Intravenous; Kinetics; Lung; Lung Diseases; Male; Middle Aged; Pectoralis Muscles; Postoperative Complications

Cefmenoxime (CMX) was administered to protect against postoperative infections in 52 cases of cesarean section and 50 cases of total abdominal hysterectomy. These two represent common operations in the gynecological field. Group I was given the agent at a total dose of 14 g (postoperatively 4, 4, 2, 2 and 2 g), group II at a total dose of 10 g (postoperatively 2, 2, 2, 2 and 2 g) and group III at a total dose of 10 g (2 g during operation and postoperatively 2, 2, 2 and 2 g). 1. When comparing the fever index between the groups, group III showed the lowest level regardless of the type of operation. 2. When comparing clinical test values between the groups, low values of white blood cell count (P less than 0.05, P less than 0.01) and erythrocyte sedimentation rate (P less than 0.05) were observed in group III with cesarean section, and significant decreases in white blood cell count (P less than 0.05) and CRP (P less than 0.01, P less than 0.001) were observed in group III with total abdominal hysterectomy. The above results indicate that the administration of CMX during operation was the most effective method of administration for protection against postoperative infections in terms of changes in fever index and clinical test values.

Topics: Adult; Bacterial Infections; Cefmenoxime; Cefotaxime; Cesarean Section; Drug Evaluation; Drug Resistance, Microbial; Female; Humans; Hysterectomy; Infusions, Parenteral; Middle Aged; Postoperative Complications; Pregnancy; Premedication