cefixime has been researched along with Syphilis in 4 studies
Cefixime: A third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases.
cefixime : A third-generation cephalosporin antibiotic bearing vinyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It is used in the treatment of gonorrhoea, tonsilitis, pharyngitis, bronchitis, and urinary tract infections.
Syphilis: A contagious venereal disease caused by the spirochete TREPONEMA PALLIDUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Demonstration of efficacy of cefixime in the treatment of active syphilis in this Phase 2 trial among non-pregnant women will inform a proposed randomized controlled trial to evaluate cefixime as an alternative treatment for pregnant women with active syphilis to evaluate prevention of congenital syphilis." | 7.96 | Phase II trial evaluating the clinical efficacy of cefixime for treatment of active syphilis in non-pregnant women in Brazil (CeBra). ( Araujo, MAL; Bazzo, ML; Bermudez, XPD; Branco Coelho, IC; Broutet, N; Habib, N; Kara, EO; Mello, MB; Mendes Pereira, GF; Miranda, AE; Nguyen, MH; Pereira Giozza, S; Silveira, MF; Taylor, MM; Thwin, SS, 2020) |
| "Demonstration of efficacy of cefixime in the treatment of active syphilis in this Phase 2 trial among non-pregnant women will inform a proposed randomized controlled trial to evaluate cefixime as an alternative treatment for pregnant women with active syphilis to evaluate prevention of congenital syphilis." | 3.96 | Phase II trial evaluating the clinical efficacy of cefixime for treatment of active syphilis in non-pregnant women in Brazil (CeBra). ( Araujo, MAL; Bazzo, ML; Bermudez, XPD; Branco Coelho, IC; Broutet, N; Habib, N; Kara, EO; Mello, MB; Mendes Pereira, GF; Miranda, AE; Nguyen, MH; Pereira Giozza, S; Silveira, MF; Taylor, MM; Thwin, SS, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (75.00) | 2.80 |
| Authors | Studies |
|---|---|
| Taylor, MM | 1 |
| Kara, EO | 1 |
| Araujo, MAL | 1 |
| Silveira, MF | 1 |
| Miranda, AE | 1 |
| Branco Coelho, IC | 1 |
| Bazzo, ML | 1 |
| Mendes Pereira, GF | 1 |
| Pereira Giozza, S | 1 |
| Bermudez, XPD | 1 |
| Mello, MB | 1 |
| Habib, N | 1 |
| Nguyen, MH | 1 |
| Thwin, SS | 1 |
| Broutet, N | 1 |
| Mehta, SN | 1 |
| Stafylis, C | 2 |
| Tellalian, DM | 1 |
| Burian, PL | 1 |
| Okada, CM | 1 |
| Millner, CE | 1 |
| Mejia, CM | 1 |
| Klausner, JD | 2 |
| Keith, K | 1 |
| Mehta, S | 1 |
| Tellalian, D | 1 |
| Burian, P | 1 |
| Millner, C | 1 |
| Farley, TA | 1 |
| Cohen, DA | 1 |
| Kahn, RH | 1 |
| Lolis, S | 1 |
| Johnson, G | 1 |
| Martin, DH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Trial Evaluating the Clinical Efficacy of Cefixime for Treatment of Early Syphilis in Non-pregnant Women[NCT03752112] | Phase 1/Phase 2 | 180 participants (Anticipated) | Interventional | 2019-11-22 | Recruiting | ||
| Clinical Trial Evaluating the Clinical Efficacy of Cefixime for Treatment of Early Syphilis[NCT03660488] | Phase 2 | 58 participants (Actual) | Interventional | 2018-09-03 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
subjects who have a 4-fold decrease (from study entry Rapid plasma reagin) in Rapid plasma reagintiters from baseline at 3 or 6 months will be considered a positive treatment response. (NCT03660488)
Timeframe: 3 or 6 months after treatment completion
| Intervention | Participants (Count of Participants) |
|---|---|
| Benzathine Penicillin G | 14 |
| Cefixime Group | 13 |
3 trials available for cefixime and Syphilis
| Article | Year |
|---|---|
Clinical trial protocol to evaluate the efficacy of cefixime in the treatment of early syphilis.
Topics: Adolescent; Anti-Bacterial Agents; Cefixime; HIV Infections; Homosexuality, Male; Humans; Male; Rand | 2020 |
Clinical Efficacy of Cefixime for the Treatment of Early Syphilis.
Topics: Anti-Bacterial Agents; Cefixime; Humans; Pilot Projects; Syphilis; Syphilis Serodiagnosis; Treatment | 2021 |
The acceptability and behavioral effects of antibiotic prophylaxis for syphilis prevention.
Topics: Adolescent; Adult; Antibiotic Prophylaxis; Azithromycin; Cefixime; Cohort Studies; Drug Administrati | 2003 |
1 other study available for cefixime and Syphilis
| Article | Year |
|---|---|
Phase II trial evaluating the clinical efficacy of cefixime for treatment of active syphilis in non-pregnant women in Brazil (CeBra).
Topics: Anti-Bacterial Agents; Brazil; Cefixime; Clinical Trial Protocols as Topic; Clinical Trials, Phase I | 2020 |