Page last updated: 2024-10-24

cefixime and Great Pox

cefixime has been researched along with Great Pox in 4 studies

Cefixime: A third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases.
cefixime : A third-generation cephalosporin antibiotic bearing vinyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It is used in the treatment of gonorrhoea, tonsilitis, pharyngitis, bronchitis, and urinary tract infections.

Research Excerpts

ExcerptRelevanceReference
"Demonstration of efficacy of cefixime in the treatment of active syphilis in this Phase 2 trial among non-pregnant women will inform a proposed randomized controlled trial to evaluate cefixime as an alternative treatment for pregnant women with active syphilis to evaluate prevention of congenital syphilis."7.96Phase II trial evaluating the clinical efficacy of cefixime for treatment of active syphilis in non-pregnant women in Brazil (CeBra). ( Araujo, MAL; Bazzo, ML; Bermudez, XPD; Branco Coelho, IC; Broutet, N; Habib, N; Kara, EO; Mello, MB; Mendes Pereira, GF; Miranda, AE; Nguyen, MH; Pereira Giozza, S; Silveira, MF; Taylor, MM; Thwin, SS, 2020)
"Demonstration of efficacy of cefixime in the treatment of active syphilis in this Phase 2 trial among non-pregnant women will inform a proposed randomized controlled trial to evaluate cefixime as an alternative treatment for pregnant women with active syphilis to evaluate prevention of congenital syphilis."3.96Phase II trial evaluating the clinical efficacy of cefixime for treatment of active syphilis in non-pregnant women in Brazil (CeBra). ( Araujo, MAL; Bazzo, ML; Bermudez, XPD; Branco Coelho, IC; Broutet, N; Habib, N; Kara, EO; Mello, MB; Mendes Pereira, GF; Miranda, AE; Nguyen, MH; Pereira Giozza, S; Silveira, MF; Taylor, MM; Thwin, SS, 2020)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's0 (0.00)24.3611
2020's3 (75.00)2.80

Authors

AuthorsStudies
Taylor, MM1
Kara, EO1
Araujo, MAL1
Silveira, MF1
Miranda, AE1
Branco Coelho, IC1
Bazzo, ML1
Mendes Pereira, GF1
Pereira Giozza, S1
Bermudez, XPD1
Mello, MB1
Habib, N1
Nguyen, MH1
Thwin, SS1
Broutet, N1
Mehta, SN1
Stafylis, C2
Tellalian, DM1
Burian, PL1
Okada, CM1
Millner, CE1
Mejia, CM1
Klausner, JD2
Keith, K1
Mehta, S1
Tellalian, D1
Burian, P1
Millner, C1
Farley, TA1
Cohen, DA1
Kahn, RH1
Lolis, S1
Johnson, G1
Martin, DH1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Trial Evaluating the Clinical Efficacy of Cefixime for Treatment of Early Syphilis in Non-pregnant Women[NCT03752112]Phase 1/Phase 2180 participants (Anticipated)Interventional2019-11-22Recruiting
Clinical Trial Evaluating the Clinical Efficacy of Cefixime for Treatment of Early Syphilis[NCT03660488]Phase 258 participants (Actual)Interventional2018-09-03Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Treatment Response

subjects who have a 4-fold decrease (from study entry Rapid plasma reagin) in Rapid plasma reagintiters from baseline at 3 or 6 months will be considered a positive treatment response. (NCT03660488)
Timeframe: 3 or 6 months after treatment completion

InterventionParticipants (Count of Participants)
Benzathine Penicillin G14
Cefixime Group13

Trials

3 trials available for cefixime and Great Pox

ArticleYear
Clinical trial protocol to evaluate the efficacy of cefixime in the treatment of early syphilis.
    Trials, 2020, Dec-09, Volume: 21, Issue:1

    Topics: Adolescent; Anti-Bacterial Agents; Cefixime; HIV Infections; Homosexuality, Male; Humans; Male; Rand

2020
Clinical Efficacy of Cefixime for the Treatment of Early Syphilis.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021, 09-07, Volume: 73, Issue:5

    Topics: Anti-Bacterial Agents; Cefixime; Humans; Pilot Projects; Syphilis; Syphilis Serodiagnosis; Treatment

2021
The acceptability and behavioral effects of antibiotic prophylaxis for syphilis prevention.
    Sexually transmitted diseases, 2003, Volume: 30, Issue:11

    Topics: Adolescent; Adult; Antibiotic Prophylaxis; Azithromycin; Cefixime; Cohort Studies; Drug Administrati

2003

Other Studies

1 other study available for cefixime and Great Pox

ArticleYear
Phase II trial evaluating the clinical efficacy of cefixime for treatment of active syphilis in non-pregnant women in Brazil (CeBra).
    BMC infectious diseases, 2020, Jun-10, Volume: 20, Issue:1

    Topics: Anti-Bacterial Agents; Brazil; Cefixime; Clinical Trial Protocols as Topic; Clinical Trials, Phase I

2020