Page last updated: 2024-10-24

cefixime and Diarrhea

cefixime has been researched along with Diarrhea in 15 studies

Cefixime: A third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases.
cefixime : A third-generation cephalosporin antibiotic bearing vinyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It is used in the treatment of gonorrhoea, tonsilitis, pharyngitis, bronchitis, and urinary tract infections.

Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.

Research Excerpts

ExcerptRelevanceReference
"Cefixime, a new third generation oral cephalosporin antibiotic, was evaluated for safety and efficacy in the treatment of 206 children with acute bacterial pharyngitis, cystitis or pneumonia."9.06Noncomparative, open label, multicenter trial of cefixime for treatment of bacterial pharyngitis, cystitis and pneumonia in pediatric patients. ( Barone, JS; Clark, PA; Risser, WL; Simpkins, DL, 1987)
"Without cefixime, diarrhea was dose limiting at irinotecan 45 mg/m2/d."5.12Cefixime allows greater dose escalation of oral irinotecan: a phase I study in pediatric patients with refractory solid tumors. ( Billups, C; Crews, KR; Daw, NC; Dome, JS; Furman, WL; Gajjar, AJ; Houghton, PJ; Panetta, JC; Patrick, CC; Rodriguez-Galindo, C; Santana, VM; Stewart, CF; Wu, J, 2006)
"Cefixime, a new third generation oral cephalosporin antibiotic, was evaluated for safety and efficacy in the treatment of 206 children with acute bacterial pharyngitis, cystitis or pneumonia."5.06Noncomparative, open label, multicenter trial of cefixime for treatment of bacterial pharyngitis, cystitis and pneumonia in pediatric patients. ( Barone, JS; Clark, PA; Risser, WL; Simpkins, DL, 1987)
"The clinical and laboratory safety of cefixime based on analysis of data from 1575 adults (1118 treated daily and 457 treated twice a day) and 615 children (299 treated daily and 316 treated twice a day) in studies of urinary tract and lower and upper respiratory tract infections (including otitis media) is reviewed."5.06Safety profile of cefixime. ( Cartwright, K; Desjardins, RE; McCarthy, EF; Tally, FP, 1987)
"Gastrointestinal toxicity, such as late-onset diarrhea, is a significant concern in irinotecan hydrochloride (CPT-11)-containing regimens."3.83Organic Anion Transporting Polypeptide (OATP)2B1 Contributes to Gastrointestinal Toxicity of Anticancer Drug SN-38, Active Metabolite of Irinotecan Hydrochloride. ( Fujita, D; Nakanishi, T; Saito, Y; Tamai, I, 2016)
"A clinical study of cefixime (CFIX), a new oral cephalosporin, was carried out to evaluate its therapeutic effectiveness on bacterial infections in children."3.67[Clinical studies on cefixime in pediatrics]. ( Endo, S; Hosoda, T; Masuda, M; Mimoto, H; Miyao, M; Tanaka, H; Yuasa, Y, 1986)
"Cefixime is a cephalosporin antibiotic that is more active against Proteus spp."1.28An improved selective medium for the isolation of Escherichia coli O157. ( Chapman, PA; Jewes, L; Siddons, CA; Zadik, PM, 1991)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19903 (20.00)18.7374
1990's6 (40.00)18.2507
2000's3 (20.00)29.6817
2010's3 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Novembre, E1
Mori, F1
Barni, S1
Pucci, N1
Rogawski, ET1
Westreich, DJ1
Becker-Dreps, S1
Adair, LS1
Sandler, RS1
Sarkar, R1
Kattula, D1
Ward, HD1
Meshnick, SR1
Kang, G1
Fujita, D1
Saito, Y1
Nakanishi, T1
Tamai, I1
Furman, WL1
Crews, KR1
Billups, C1
Wu, J1
Gajjar, AJ1
Daw, NC1
Patrick, CC1
Rodriguez-Galindo, C1
Stewart, CF1
Dome, JS1
Panetta, JC1
Houghton, PJ1
Santana, VM1
Gales, MA1
Gales, BJ1
Chachaty, E1
Bourneix, C1
Renard, S1
Bonnay, M1
Andremont, A1
Chapman, PA2
Siddons, CA2
Hornitzky, MA1
Bettelheim, KA1
Djordjevic, SP1
Bartlett, JG1
Zadik, PM1
Jewes, L1
Piippo, T1
Stefansson, S1
Pitkäjärvi, T1
Lundberg, C1
Risser, WL1
Barone, JS1
Clark, PA1
Simpkins, DL1
Tally, FP1
Desjardins, RE1
McCarthy, EF1
Cartwright, K1
Hosoda, T1
Masuda, M1
Miyao, M1
Mimoto, H1
Endo, S1
Yuasa, Y1
Tanaka, H1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
"A Multicenter Randomized Controlled Trial to Establish the Impact of MeMed BV® on Management of Patients With Suspected Lower Respiratory Tract Infections (LRTI) in the Emergency Department (ED) and Urgent Care Center (UCC) (JUPITER TRIAL)"[NCT05762302]1,316 participants (Anticipated)Interventional2023-01-31Recruiting
Fecal Calprotectin Level in Differentiating Between Inflammatory and Non-inflammatory Diarrhea in Patients With Nosocomial Diarrhea[NCT04491799]135 participants (Actual)Observational2019-02-01Completed
Evaluation of the Impact of an Amoxicillin and Amoxicillin/Clavulanic Acid Resistant Probiotic on Key Clinical Outcomes in Children Treated With Amoxicillin or Amoxicillin/Clavulanic Acid[NCT05840588]300 participants (Anticipated)Interventional2023-04-10Recruiting
Efficacy of the Application of Moxifloxacin and Cefixime in Reduction of Inflammatory Sequelae and Complications After Mandibular Third Molar Surgery[NCT05027893]157 participants (Actual)Interventional2019-06-07Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for cefixime and Diarrhea

ArticleYear
Clinical practice. Antibiotic-associated diarrhea.
    The New England journal of medicine, 2002, Jan-31, Volume: 346, Issue:5

    Topics: Anti-Bacterial Agents; Cefixime; Clostridioides difficile; Colon; Diagnosis, Differential; Diarrhea;

2002
Clinical practice. Antibiotic-associated diarrhea.
    The New England journal of medicine, 2002, Jan-31, Volume: 346, Issue:5

    Topics: Anti-Bacterial Agents; Cefixime; Clostridioides difficile; Colon; Diagnosis, Differential; Diarrhea;

2002
Clinical practice. Antibiotic-associated diarrhea.
    The New England journal of medicine, 2002, Jan-31, Volume: 346, Issue:5

    Topics: Anti-Bacterial Agents; Cefixime; Clostridioides difficile; Colon; Diagnosis, Differential; Diarrhea;

2002
Clinical practice. Antibiotic-associated diarrhea.
    The New England journal of medicine, 2002, Jan-31, Volume: 346, Issue:5

    Topics: Anti-Bacterial Agents; Cefixime; Clostridioides difficile; Colon; Diagnosis, Differential; Diarrhea;

2002
Clinical practice. Antibiotic-associated diarrhea.
    The New England journal of medicine, 2002, Jan-31, Volume: 346, Issue:5

    Topics: Anti-Bacterial Agents; Cefixime; Clostridioides difficile; Colon; Diagnosis, Differential; Diarrhea;

2002
Clinical practice. Antibiotic-associated diarrhea.
    The New England journal of medicine, 2002, Jan-31, Volume: 346, Issue:5

    Topics: Anti-Bacterial Agents; Cefixime; Clostridioides difficile; Colon; Diagnosis, Differential; Diarrhea;

2002
Clinical practice. Antibiotic-associated diarrhea.
    The New England journal of medicine, 2002, Jan-31, Volume: 346, Issue:5

    Topics: Anti-Bacterial Agents; Cefixime; Clostridioides difficile; Colon; Diagnosis, Differential; Diarrhea;

2002
Clinical practice. Antibiotic-associated diarrhea.
    The New England journal of medicine, 2002, Jan-31, Volume: 346, Issue:5

    Topics: Anti-Bacterial Agents; Cefixime; Clostridioides difficile; Colon; Diagnosis, Differential; Diarrhea;

2002
Clinical practice. Antibiotic-associated diarrhea.
    The New England journal of medicine, 2002, Jan-31, Volume: 346, Issue:5

    Topics: Anti-Bacterial Agents; Cefixime; Clostridioides difficile; Colon; Diagnosis, Differential; Diarrhea;

2002

Trials

4 trials available for cefixime and Diarrhea

ArticleYear
Cefixime allows greater dose escalation of oral irinotecan: a phase I study in pediatric patients with refractory solid tumors.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Feb-01, Volume: 24, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Phytogenic; Camptothecin; Cefixime;

2006
Double-blind comparison of cefixime and cefaclor in the treatment of acute otitis media in children.
    Scandinavian journal of infectious diseases, 1991, Volume: 23, Issue:4

    Topics: Acute Disease; Anti-Bacterial Agents; Cefaclor; Cefixime; Cefotaxime; Child; Child, Preschool; Diarr

1991
Noncomparative, open label, multicenter trial of cefixime for treatment of bacterial pharyngitis, cystitis and pneumonia in pediatric patients.
    The Pediatric infectious disease journal, 1987, Volume: 6, Issue:10

    Topics: Adolescent; Cefixime; Cefotaxime; Child; Child, Preschool; Clinical Trials as Topic; Cystitis; Diarr

1987
Safety profile of cefixime.
    The Pediatric infectious disease journal, 1987, Volume: 6, Issue:10

    Topics: Adult; Cefixime; Cefotaxime; Child; Child, Preschool; Clinical Trials as Topic; Diarrhea; Drug Admin

1987

Other Studies

10 other studies available for cefixime and Diarrhea

ArticleYear
Drug-induced enterocolitis syndrome (DIES).
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2014, Volume: 25, Issue:4

    Topics: Amoxicillin; Anti-Bacterial Agents; Cefixime; Child; Dairy Products; Diarrhea; Drug Eruptions; Drug

2014
Antibiotic treatment of diarrhoea is associated with decreased time to the next diarrhoea episode among young children in Vellore, India.
    International journal of epidemiology, 2015, Volume: 44, Issue:3

    Topics: Anti-Bacterial Agents; Cefixime; Child, Preschool; Diarrhea; Female; Humans; India; Infant; Infant,

2015
Organic Anion Transporting Polypeptide (OATP)2B1 Contributes to Gastrointestinal Toxicity of Anticancer Drug SN-38, Active Metabolite of Irinotecan Hydrochloride.
    Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:1

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Bacteria; Bacterial Proteins; Camptothecin; Ce

2016
Recognition of severe cefixime-induced diarrhea.
    Clinical pharmacy, 1993, Volume: 12, Issue:12

    Topics: Anti-Infective Agents; Cefixime; Cefotaxime; Diarrhea; Female; Humans; Middle Aged

1993
Shedding of Clostridium difficile, fecal beta-lactamase activity, and gastrointestinal symptoms in 51 volunteers treated with oral cefixime.
    Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; beta-Lactamases; Cefixime; Cefotaxim

1993
A comparison of immunomagnetic separation and direct culture for the isolation of verocytotoxin-producing Escherichia coli O157 from cases of bloody diarrhoea, non-bloody diarrhoea and asymptomatic contacts.
    Journal of medical microbiology, 1996, Volume: 44, Issue:4

    Topics: Acute Disease; Animals; Anti-Bacterial Agents; Bacterial Toxins; Bacteriophage Typing; Cefixime; Cef

1996
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 19-1998. A 70-year-old man with diarrhea, polyarthritis, and a history of Reiter's syndrome.
    The New England journal of medicine, 1998, Jun-18, Volume: 338, Issue:25

    Topics: Aged; Arthritis; Arthritis, Reactive; Cefixime; Cefotaxime; Cephalosporins; Clostridioides difficile

1998
The detection of Shiga toxin-producing Escherichia coli in diagnostic bovine faecal samples using vancomycin-cefixime-cefsulodin blood agar and PCR.
    FEMS microbiology letters, 2001, Apr-20, Volume: 198, Issue:1

    Topics: Adhesins, Bacterial; Animals; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacteriological

2001
An improved selective medium for the isolation of Escherichia coli O157.
    Journal of medical microbiology, 1991, Volume: 35, Issue:2

    Topics: Anti-Infective Agents, Urinary; Bacterial Toxins; Cefixime; Cefotaxime; Culture Media; Diarrhea; Esc

1991
[Clinical studies on cefixime in pediatrics].
    The Japanese journal of antibiotics, 1986, Volume: 39, Issue:4

    Topics: Bacteria; Bacterial Infections; Cefixime; Cefotaxime; Chemical and Drug Induced Liver Injury; Child;

1986