cefiderocol and Body-Weight

cefiderocol has been researched along with Body-Weight* in 1 studies

Trials

1 trial(s) available for cefiderocol and Body-Weight

Article	Year
Population Pharmacokinetic Analysis of Cefiderocol, a Parenteral Siderophore Cephalosporin, in Healthy Subjects, Subjects with Various Degrees of Renal Function, and Patients with Complicated Urinary Tract Infection or Acute Uncomplicated Pyelonephritis. Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:2 Cefiderocol, a novel parenteral siderophore cephalosporin, exhibits potent efficacy against most Gram-negative bacteria, including carbapenem-resistant strains. The aim of this study was to perform a population pharmacokinetic (PK) analysis based on plasma cefiderocol concentrations in healthy subjects, subjects with various degrees of renal function, and patients with complicated urinary tract infection (cUTI) or acute uncomplicated pyelonephritis (AUP) caused by Gram-negative pathogens and to calculate the fraction of the time during the dosing interval where the free drug concentration in plasma exceeds the MIC ( Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Body Weight; Case-Control Studies; Cefiderocol; Cephalosporins; Creatinine; Drug Administration Schedule; Female; Glomerular Filtration Rate; Gram-Negative Bacterial Infections; Humans; Male; Middle Aged; Models, Statistical; Pyelonephritis; Renal Insufficiency, Chronic; Severity of Illness Index; Siderophores; Urinary Tract Infections	2018

Article

Year

Population Pharmacokinetic Analysis of Cefiderocol, a Parenteral Siderophore Cephalosporin, in Healthy Subjects, Subjects with Various Degrees of Renal Function, and Patients with Complicated Urinary Tract Infection or Acute Uncomplicated Pyelonephritis.

Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:2

Cefiderocol, a novel parenteral siderophore cephalosporin, exhibits potent efficacy against most Gram-negative bacteria, including carbapenem-resistant strains. The aim of this study was to perform a population pharmacokinetic (PK) analysis based on plasma cefiderocol concentrations in healthy subjects, subjects with various degrees of renal function, and patients with complicated urinary tract infection (cUTI) or acute uncomplicated pyelonephritis (AUP) caused by Gram-negative pathogens and to calculate the fraction of the time during the dosing interval where the free drug concentration in plasma exceeds the MIC (

Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Body Weight; Case-Control Studies; Cefiderocol; Cephalosporins; Creatinine; Drug Administration Schedule; Female; Glomerular Filtration Rate; Gram-Negative Bacterial Infections; Humans; Male; Middle Aged; Models, Statistical; Pyelonephritis; Renal Insufficiency, Chronic; Severity of Illness Index; Siderophores; Urinary Tract Infections

2018