cefatrizine and Bacterial-Infections

Eight Italian clinical centers carried out a controlled double-blind/double-dummy evaluation of the effectiveness of two different administration schedules of cefatrizine, an orally active cephalosporin. The first schedule provided for once-a-day administration of 1.5 gm of the drug, and the second one for twice-a-day administration of 0.75 gm. The trial included 160 patients affected by bacterial diseases of the respiratory apparatus. The two drug administration schedules were found to be equivalent in clinical and bacteriological results and in tolerability.

Topics: Adult; Bacterial Infections; Cefatrizine; Cephalosporins; Double-Blind Method; Female; Humans; Male; Multicenter Studies as Topic; Patient Compliance; Randomized Controlled Trials as Topic

Cefatrizine, a new oral cephalosporin, proved effective in the treatment of a wide range of bacterial infections in both adult and paediatric patients. Adverse reactions mild and mainly limited to gastrointestinal disturbances.

Topics: Bacterial Infections; Cefatrizine; Cephalosporins; Clinical Trials as Topic; Drug Administration Schedule; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests

The Authors evaluated the cefatrizine clinical effects on 50 patients with infectious diseases. The statistical analysis of results show a high efficacy and safety with no relevant side effects.

Topics: Adolescent; Adult; Aged; Bacterial Infections; Cefatrizine; Cephalosporins; Child; Female; Humans; Male; Middle Aged; Mouth Diseases

Levels of cefatrizine, a new oral cephalosporin, were determined in blood and in tonsils, paranasal sinus secretions and middle ear exudates from 18 patients with acute infections at these sites. Three and six hours after administration of 500 mg cefatrizine satisfactory levels of the antibiotic were found at all the sites examined. Levels in the tonsils and middle ear were higher than those in blood, while lower levels were recorded in nasal secretions.

Topics: Bacterial Infections; Cefatrizine; Cephalosporins; Ear, Middle; Humans; Kinetics; Palatine Tonsil; Paranasal Sinuses

Topics: Bacterial Infections; Cefatrizine; Cephalosporins; Humans; Intestinal Absorption; Kinetics; Microbial Sensitivity Tests

A study was carried out in 12 patients, divided into two groups of 6, to determine tissue levels of cefatrizine in lung (group I) and bronchial secretions (group II) following a single oral dose of 500 mg. In group I, specimens of blood and lung tissue were collected after 2 h from one subgroup of 3 patients and after 3 h from the other subgroup of 3. Average levels were 8.5 and 7.0 mcg/ml for blood and 1.2 and 1.4 mcg/ml for lung tissue respectively. In group II blood and bronchial secretion concentrations were evaluated at the 2nd, 3rd and 6th hours from administration. Average values were 9.1 and 7.7 mcg/ml in blood at 2h and 3h respectively, whereas the average bronchial secretion concentration at the 3rd hour was 10.4 mcg/ml in the first subgroup. In the second subgroup the mean level in blood collected at the 2nd hour was 8.9 mcg/ml, and 2.5 and 4.1 mcg/ml respectively in blood and bronchial secretions at the 6th hour. Cefatrizine levels in bronchial secretions were higher than those in blood at both the 3rd and the 6th hour from administration: this kinetic peculiarity of the drug will doubtless play an important role in the therapeutic efficacy of cefatrizine.

Topics: Bacterial Infections; Cefatrizine; Cephalosporins; Humans; Kinetics; Lung

Topics: Acute Disease; Administration, Oral; Aged; Bacterial Infections; Cefatrizine; Cephalosporins; Female; Humans; Male; Middle Aged; Respiratory Tract Infections

Topics: Adult; Aged; Bacterial Infections; Cefatrizine; Cephalosporins; Drug Evaluation; Female; Genital Diseases, Female; Humans; Middle Aged; Urinary Tract Infections