cefamandole and Prostatic-Hyperplasia

cefamandole has been researched along with Prostatic-Hyperplasia* in 2 studies

Other Studies

2 other study(ies) available for cefamandole and Prostatic-Hyperplasia

Article	Year
[A pharmacokinetic study of diffusion in adenomatous prostatic tissue of an intravenous bolus of cefamandole]. Annales d'urologie, 1990, Volume: 24, Issue:2 Twenty-three patients undergoing transurethral resection of the prostate for benign prostatic hypertrophy received antibiotic prophylaxis with a second generation cephalosporin, cefamandole, administered by a single IV bolus of 2.5 g. A pharmacokinetic study was performed on blood and resection chips collected at regular intervals. Cefamandole penetrates rapidly into the prostate without any saturation threshold. It diffuses less extensively and persists for a shorter period in elderly subjects, but penetrates to an identical degree regardless of the volume of the adenoma. The prostatic concentration was always higher than the minimal inhibitory concentration for the bacteria generally encountered, except for pseudomonas. The pharmacokinetic study of cefamandole therefore demonstrated that an IV bolus of 2.5 g is perfectly suitable for antibiotic prophylaxis prior to prostatic resection. Topics: Absorption; Aged; Aged, 80 and over; Biological Availability; Cefamandole; Chromatography, High Pressure Liquid; Creatinine; Humans; Injections, Intravenous; Male; Middle Aged; Premedication; Prostate; Prostatic Hyperplasia	1990
[Diffusion of cefamandole into the prostatic tissue (author's transl)]. Medizinische Klinik, 1979, Feb-16, Volume: 74, Issue:7 From 21 patients with prostatic adenoma with an average age of 69 years, serum and prostatic tissue concentrations after a single i.v. dose of 2 grams of cefamandole were estimated. The mean serum concentrations 30 minutes after the infusion was completed, were measured with 104.8 and after 60 minutes with 51 microgram/ml. The corresponding concentrations in the prostatic adenoma tissue were after 30 minutes 32.87 and after 60 minutes 17.1 microgram/g. These data are compared with earlier findings with other caphalosporine antibiotics (cephradine, cephapirine, cephacetrile, cephalothin) in the same tissue materials at the same time points. The estimated concentrations of cefamandole in serum and prostatic tissue are suited for the treatment of infections caused by cefamandole sensitive microorganisms. Topics: Aged; Cefamandole; Cephalosporins; Humans; Male; Middle Aged; Prostate; Prostatic Hyperplasia	1979

Article

Year

[A pharmacokinetic study of diffusion in adenomatous prostatic tissue of an intravenous bolus of cefamandole].

Annales d'urologie, 1990, Volume: 24, Issue:2

Twenty-three patients undergoing transurethral resection of the prostate for benign prostatic hypertrophy received antibiotic prophylaxis with a second generation cephalosporin, cefamandole, administered by a single IV bolus of 2.5 g. A pharmacokinetic study was performed on blood and resection chips collected at regular intervals. Cefamandole penetrates rapidly into the prostate without any saturation threshold. It diffuses less extensively and persists for a shorter period in elderly subjects, but penetrates to an identical degree regardless of the volume of the adenoma. The prostatic concentration was always higher than the minimal inhibitory concentration for the bacteria generally encountered, except for pseudomonas. The pharmacokinetic study of cefamandole therefore demonstrated that an IV bolus of 2.5 g is perfectly suitable for antibiotic prophylaxis prior to prostatic resection.

Topics: Absorption; Aged; Aged, 80 and over; Biological Availability; Cefamandole; Chromatography, High Pressure Liquid; Creatinine; Humans; Injections, Intravenous; Male; Middle Aged; Premedication; Prostate; Prostatic Hyperplasia

1990

[Diffusion of cefamandole into the prostatic tissue (author's transl)].

Medizinische Klinik, 1979, Feb-16, Volume: 74, Issue:7

From 21 patients with prostatic adenoma with an average age of 69 years, serum and prostatic tissue concentrations after a single i.v. dose of 2 grams of cefamandole were estimated. The mean serum concentrations 30 minutes after the infusion was completed, were measured with 104.8 and after 60 minutes with 51 microgram/ml. The corresponding concentrations in the prostatic adenoma tissue were after 30 minutes 32.87 and after 60 minutes 17.1 microgram/g. These data are compared with earlier findings with other caphalosporine antibiotics (cephradine, cephapirine, cephacetrile, cephalothin) in the same tissue materials at the same time points. The estimated concentrations of cefamandole in serum and prostatic tissue are suited for the treatment of infections caused by cefamandole sensitive microorganisms.

Topics: Aged; Cefamandole; Cephalosporins; Humans; Male; Middle Aged; Prostate; Prostatic Hyperplasia

1979