cefamandole and Hemorrhagic-Disorders

A 87-year-old patient developed coagulation abnormality following hip surgery related to the prophylactic use of cefamandole. Cefamandole as others cephalosporins with a methyl-tetrazol-thiol lateral chain interferes with the vitamin K regeneration cycle as do oral anticoagulants. Therefore, the use of others antibiotics or systematic vitamin K1 supplementation or single dose of cefamandole is recommended for patients with renal failure or with malnutrition. Vitamin K1 supplementation is a simple method resulting in complete resolution of the coagulation disorder.

Topics: Aged; Aged, 80 and over; Antibiotic Prophylaxis; Arthroplasty, Replacement, Hip; Cefamandole; Cephalosporins; Female; Femoral Neck Fractures; Hematoma; Hemorrhagic Disorders; Humans; Postoperative Complications; Vitamin K; Vitamin K Deficiency

Two patients are described with severe coagulation disturbances, in one instance leading to extensive skin bleeding, secondary to the use of cefamandole. This cefalosporin antibiotic carries the same N-methylthiotetrazole side chain as moxalactam. Pathogenetic mechanisms leading to hypoprothrombinemia, its prevention and treatment are discussed.

Topics: Aged; Amputation, Surgical; Cefamandole; Diabetic Angiopathies; Female; Hemorrhagic Disorders; Humans; Hypoprothrombinemias; Kidney Transplantation; Male; Middle Aged; Pneumonia; Postoperative Complications

Topics: Aged; Cefamandole; Female; Hemorrhagic Disorders; Humans; Hypoprothrombinemias; Male

Topics: Cefamandole; Cephalosporins; Hemorrhagic Disorders; Humans; Hypoprothrombinemias; Prothrombin Time; Vitamin K