cefamandole and Fetal-Membranes--Premature-Rupture

cefamandole has been researched along with Fetal-Membranes--Premature-Rupture* in 2 studies

Trials

2 trial(s) available for cefamandole and Fetal-Membranes--Premature-Rupture

Article	Year
Cesarean prophylaxis: a comparison of cefamandole and cefazolin by both intravenous and lavage routes, and risk factors associated with endometritis. Obstetrics and gynecology, 1990, Volume: 75, Issue:2 This study included 207 patients in a double-blind, prospective randomized trial of cefazolin versus cefamandole single-dose prophylaxis by both intravenous (IV) and lavage routes in patients laboring with ruptured membranes who eventually had nonelective cesareans. No significant differences (P less than .05) were noted in the rates of infectious morbidity (cefazolin IV: six of 47, 13%; cefazolin lavage: nine of 59, 15%; cefamandole IV: six of 47, 13%; cefamandole lavage: six of 54, 11%). The incidence of operative complications in the patients developing endometritis (eight of 22, 36%) was significantly different (P less than .004) from that in the group who did not develop endometritis (21 of 185, 11%). Cefazolin by IV and lavage routes of administration appears to be as effective as cefamandole by either route of administration. Topics: Cefamandole; Cefazolin; Cesarean Section; Double-Blind Method; Endometritis; Female; Fetal Membranes, Premature Rupture; Humans; Incidence; Injections, Intravenous; Pregnancy; Prospective Studies; Puerperal Infection; Randomized Controlled Trials as Topic; Risk Factors; Therapeutic Irrigation	1990
Perioperative cephalosporin prophylaxis in cesarean section: effect on endometritis in the high-risk patient. American journal of obstetrics and gynecology, 1979, Aug-15, Volume: 134, Issue:8 A total of 120 patients who were to be delivered by cesarean section and who were at high risk of postoperative infection received three doses of either cefamandole, cephalothin or placebo perioperatively. Maternal serum levels for both antibiotics were in the therapeutic range. Although both drugs reduced the incidence of febrile morbidity and endometritis, only cefamandole significantly reduced the fever index. Risk factors for postoperative infections were the presence of ruptured membranes, labor, and internal fetal monitoring. Cefamandole beneficially influenced all risk factors while cephalothin was able to reduce only the risk of ruptured membranes. When a new method for obtaining endometrial tissue was utilized, 50% of cultures were negative. There was no difference in the organisms isolated from patients with and without endometritis. Topics: Adult; Cefamandole; Cephalosporins; Cephalothin; Cesarean Section; Clinical Trials as Topic; Drug Resistance, Microbial; Endometritis; Female; Fetal Blood; Fetal Membranes, Premature Rupture; Fetal Monitoring; Fever; Humans; Infant, Newborn; Labor, Obstetric; Pregnancy; Risk	1979

Article

Year

Cesarean prophylaxis: a comparison of cefamandole and cefazolin by both intravenous and lavage routes, and risk factors associated with endometritis.

Obstetrics and gynecology, 1990, Volume: 75, Issue:2

This study included 207 patients in a double-blind, prospective randomized trial of cefazolin versus cefamandole single-dose prophylaxis by both intravenous (IV) and lavage routes in patients laboring with ruptured membranes who eventually had nonelective cesareans. No significant differences (P less than .05) were noted in the rates of infectious morbidity (cefazolin IV: six of 47, 13%; cefazolin lavage: nine of 59, 15%; cefamandole IV: six of 47, 13%; cefamandole lavage: six of 54, 11%). The incidence of operative complications in the patients developing endometritis (eight of 22, 36%) was significantly different (P less than .004) from that in the group who did not develop endometritis (21 of 185, 11%). Cefazolin by IV and lavage routes of administration appears to be as effective as cefamandole by either route of administration.

Topics: Cefamandole; Cefazolin; Cesarean Section; Double-Blind Method; Endometritis; Female; Fetal Membranes, Premature Rupture; Humans; Incidence; Injections, Intravenous; Pregnancy; Prospective Studies; Puerperal Infection; Randomized Controlled Trials as Topic; Risk Factors; Therapeutic Irrigation

1990

Perioperative cephalosporin prophylaxis in cesarean section: effect on endometritis in the high-risk patient.

American journal of obstetrics and gynecology, 1979, Aug-15, Volume: 134, Issue:8

A total of 120 patients who were to be delivered by cesarean section and who were at high risk of postoperative infection received three doses of either cefamandole, cephalothin or placebo perioperatively. Maternal serum levels for both antibiotics were in the therapeutic range. Although both drugs reduced the incidence of febrile morbidity and endometritis, only cefamandole significantly reduced the fever index. Risk factors for postoperative infections were the presence of ruptured membranes, labor, and internal fetal monitoring. Cefamandole beneficially influenced all risk factors while cephalothin was able to reduce only the risk of ruptured membranes. When a new method for obtaining endometrial tissue was utilized, 50% of cultures were negative. There was no difference in the organisms isolated from patients with and without endometritis.

Topics: Adult; Cefamandole; Cephalosporins; Cephalothin; Cesarean Section; Clinical Trials as Topic; Drug Resistance, Microbial; Endometritis; Female; Fetal Blood; Fetal Membranes, Premature Rupture; Fetal Monitoring; Fever; Humans; Infant, Newborn; Labor, Obstetric; Pregnancy; Risk

1979