cefamandole and Carcinoma--Squamous-Cell

The impact on wound infection of the addition of perioperative cefamandole to a mechanical bowel preparation with oral antibiotics was studied in a prospective randomized series of patients undergoing elective colectomy for biopsy-proven carcinoma or adenomatous polyps. Seventy patients were randomized, all underwent mechanical bowel preparation and received oral neomycin and erythromycin base. Thirty-four patients also received a preoperative and four postoperative doses of cefamandole, while 36 patients were randomized to receive no parenteral antibiotics. The two groups were well stratified for age, sex, and risk factors. The Dukes stage was similar and the surgical procedures were equally distributed in the two groups. There were no wound infections in the 34 patients receiving cefamandole and only one wound infection (2.8 percent) in the 36 control patients. Therefore, the addition of perioperative intravenous cefamandole to a good mechanical bowel preparation with oral antibiotics was of no benefit in reducing wound infections following resection of colorectal malignancies in this select group of patients.

Topics: Carcinoma, Squamous Cell; Cefamandole; Colonic Neoplasms; Colonic Polyps; Female; Humans; Intestinal Polyps; Male; Middle Aged; Premedication; Prospective Studies; Random Allocation; Rectal Neoplasms; Surgical Wound Infection

From July 1, 1978 to June 30, 1984, 45 radical abdominal hysterectomies were performed by the authors at Tripler Army Medical Center. Management was uniform except for the use of prophylactic antibiotics. Three patterns of practice were identified: Group I, no antibiotics were used; Group II, intravenous (i.v.) antibiotics were given in the induction room and for less than 48 h post-surgery; Group III, prophylactic i.v. antibiotics were given and the surgical site was also irrigated with a cefamandole and saline solution. The three groups were found to be similar with regard to age, parity, weight-height index, pre- and postoperative hematocrit, pre-operative white blood cell count, operative and anesthesia times, estimated blood loss, and amount of blood transfused. Groups I and II had a higher surgical site infection rate (87.5% and 63.6%, respectively) than Group III (3.8%). The mean 10-day fever index in degree hours was 109 for Group I, 71 for Group II, and 30 for Group III (P less than 0.001). Irrigation of the surgical site with a cefamandole and saline solution in addition to i.v. antibiotics decreases the infectious morbidity of radical hysterectomy.

Topics: Adenocarcinoma; Administration, Topical; Adult; Bacterial Infections; Carcinoma, Squamous Cell; Cefamandole; Clinical Trials as Topic; Doxycycline; Female; Humans; Hysterectomy; Lymph Node Excision; Middle Aged; Postoperative Complications; Premedication; Therapeutic Irrigation; Uterine Cervical Neoplasms

Topics: Adenocarcinoma; Adult; Bacterial Infections; Bronchoalveolar Lavage Fluid; Carcinoma, Squamous Cell; Cefamandole; Glottis; Humans; Intraoperative Care; Lung Neoplasms

Osteomyelitis of the pubic bone due to anaerobic bacteria has been reported infrequently, although an entity known as "sterile" osteitis pubis is common to the literature. We have described two cases of pubic osteomyelitis due to anaerobic bacteria, discussed two previously reported cases, and suggested that most cases of what has previously been termed sterile osteitis pubis may actually have been due to anaerobic bacteria that were not isolated because of deficiencies in collection, transport, and culture of clinical specimens. Included are the pathogenesis and an approach to the treatment of this entity.

Topics: Abscess; Adult; Aged; Bacteria, Anaerobic; Bacterial Infections; Bone Marrow; Carcinoma, Squamous Cell; Cefamandole; Clindamycin; Female; Humans; Osteomyelitis; Pubic Bone; Vulvar Neoplasms