cefamandole and Adenocarcinoma

cefamandole has been researched along with Adenocarcinoma* in 3 studies

Trials

2 trial(s) available for cefamandole and Adenocarcinoma

Article	Year
Prophylactic topical cefamandole in radical hysterectomy. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1987, Volume: 25, Issue:2 From July 1, 1978 to June 30, 1984, 45 radical abdominal hysterectomies were performed by the authors at Tripler Army Medical Center. Management was uniform except for the use of prophylactic antibiotics. Three patterns of practice were identified: Group I, no antibiotics were used; Group II, intravenous (i.v.) antibiotics were given in the induction room and for less than 48 h post-surgery; Group III, prophylactic i.v. antibiotics were given and the surgical site was also irrigated with a cefamandole and saline solution. The three groups were found to be similar with regard to age, parity, weight-height index, pre- and postoperative hematocrit, pre-operative white blood cell count, operative and anesthesia times, estimated blood loss, and amount of blood transfused. Groups I and II had a higher surgical site infection rate (87.5% and 63.6%, respectively) than Group III (3.8%). The mean 10-day fever index in degree hours was 109 for Group I, 71 for Group II, and 30 for Group III (P less than 0.001). Irrigation of the surgical site with a cefamandole and saline solution in addition to i.v. antibiotics decreases the infectious morbidity of radical hysterectomy. Topics: Adenocarcinoma; Administration, Topical; Adult; Bacterial Infections; Carcinoma, Squamous Cell; Cefamandole; Clinical Trials as Topic; Doxycycline; Female; Humans; Hysterectomy; Lymph Node Excision; Middle Aged; Postoperative Complications; Premedication; Therapeutic Irrigation; Uterine Cervical Neoplasms	1987
A trial of prophylactic cefamandole in extended gynecologic surgery. Obstetrics and gynecology, 1982, Volume: 59, Issue:3 A double-blind randomized trial of antibiotic prophylaxis was performed with 49 patients undergoing extended pelvic surgery for adenocarcinoma of the endometrium. In this series infections of the Hemovac drain site(s) were most common (8 of 10 infections); only 1 serious infection, pelvic cellulitis, occurred. Short-term perioperative cefamandole therapy significantly reduced infections and febrile morbidity in these patients as compared with patients who received a placebo. The average postoperative hospital stay for patients in the cefamandole group was 1 day less than for patients in the placebo group, but the difference was not statistically significant. The presence of 10 colony-forming units or more of a potential pathogen in lymph fluid collected through the Hemovac drains correlated with clinical infection. The low incidence of serious infection in this study precludes any conclusion regarding the impact of antibiotic prophylaxis in preventing serious infection after operation for gynecologic malignancy. Topics: Adenocarcinoma; Adult; Aged; Cefamandole; Cephalosporins; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Lymph; Middle Aged; Premedication; Prospective Studies; Random Allocation; Surgical Wound Infection; Uterine Neoplasms	1982

Article

Year

Prophylactic topical cefamandole in radical hysterectomy.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1987, Volume: 25, Issue:2

From July 1, 1978 to June 30, 1984, 45 radical abdominal hysterectomies were performed by the authors at Tripler Army Medical Center. Management was uniform except for the use of prophylactic antibiotics. Three patterns of practice were identified: Group I, no antibiotics were used; Group II, intravenous (i.v.) antibiotics were given in the induction room and for less than 48 h post-surgery; Group III, prophylactic i.v. antibiotics were given and the surgical site was also irrigated with a cefamandole and saline solution. The three groups were found to be similar with regard to age, parity, weight-height index, pre- and postoperative hematocrit, pre-operative white blood cell count, operative and anesthesia times, estimated blood loss, and amount of blood transfused. Groups I and II had a higher surgical site infection rate (87.5% and 63.6%, respectively) than Group III (3.8%). The mean 10-day fever index in degree hours was 109 for Group I, 71 for Group II, and 30 for Group III (P less than 0.001). Irrigation of the surgical site with a cefamandole and saline solution in addition to i.v. antibiotics decreases the infectious morbidity of radical hysterectomy.

Topics: Adenocarcinoma; Administration, Topical; Adult; Bacterial Infections; Carcinoma, Squamous Cell; Cefamandole; Clinical Trials as Topic; Doxycycline; Female; Humans; Hysterectomy; Lymph Node Excision; Middle Aged; Postoperative Complications; Premedication; Therapeutic Irrigation; Uterine Cervical Neoplasms

1987

A trial of prophylactic cefamandole in extended gynecologic surgery.

Obstetrics and gynecology, 1982, Volume: 59, Issue:3

A double-blind randomized trial of antibiotic prophylaxis was performed with 49 patients undergoing extended pelvic surgery for adenocarcinoma of the endometrium. In this series infections of the Hemovac drain site(s) were most common (8 of 10 infections); only 1 serious infection, pelvic cellulitis, occurred. Short-term perioperative cefamandole therapy significantly reduced infections and febrile morbidity in these patients as compared with patients who received a placebo. The average postoperative hospital stay for patients in the cefamandole group was 1 day less than for patients in the placebo group, but the difference was not statistically significant. The presence of 10 colony-forming units or more of a potential pathogen in lymph fluid collected through the Hemovac drains correlated with clinical infection. The low incidence of serious infection in this study precludes any conclusion regarding the impact of antibiotic prophylaxis in preventing serious infection after operation for gynecologic malignancy.

Topics: Adenocarcinoma; Adult; Aged; Cefamandole; Cephalosporins; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Lymph; Middle Aged; Premedication; Prospective Studies; Random Allocation; Surgical Wound Infection; Uterine Neoplasms

1982

Other Studies

1 other study(ies) available for cefamandole and Adenocarcinoma

Article	Year
[Sub-glottal bacterial colonization detected by intraoperative bronchioloalveolar lavage on a lung fragment during pulmonary resection]. Presse medicale (Paris, France : 1983), 1994, Feb-05, Volume: 23, Issue:4 Topics: Adenocarcinoma; Adult; Bacterial Infections; Bronchoalveolar Lavage Fluid; Carcinoma, Squamous Cell; Cefamandole; Glottis; Humans; Intraoperative Care; Lung Neoplasms	1994