cecropin-b-protein--insecta and Carcinoma

cecropin-b-protein--insecta has been researched along with Carcinoma* in 1 studies

Other Studies

1 other study(ies) available for cecropin-b-protein--insecta and Carcinoma

ArticleYear
Induction of transient ion channel-like pores in a cancer cell by antibiotic peptide.
    Journal of biochemistry, 2004, Volume: 136, Issue:2

    The anticancer activity of anti-bacterial cecropins makes them potentially useful as peptide anti-cancer drugs. We used the cell-attached patch to study the effect of cecropin B (CB; having one hydrophobic and one amphipathic alpha-helix) and its derivative, cecropin B3 (CB3; having two hydrophobic alpha-helices) on the membrane of Ags cancer cells. Application of 10-60 microM CB onto the membrane of the cancer cell produces short outward currents. Comparative study with CB3, which induces no outward currents, shows that the amphipathic group of CB is necessary for the pore formation. The results provide a rationale to study the cell-killing activity of antimicrobial peptides at the single cancer cell level.

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; Biological Transport; Carcinoma; Cell Line, Tumor; Cell Membrane; Electrophysiology; HEPES; Humans; Insect Proteins; Ions; Lipid Bilayers; Patch-Clamp Techniques; Peptides; Tetraethylammonium; Time Factors

2004