cd4-(76-94) and Malaria

Thin blood films show that percentages of parasitaemia increases with disease progression in infections with the lethal malaria parasite and mice eventually die by day 14th post-infection. Whereas in case of non-lethal malaria parasite, parasitaemia goes down by 7th day post infection and gets cleared within 13th day. The number of CD4. Taken together, these data suggest that lethal parasite induce immunosuppressive environment, protecting from host immune responses and help the parasite to survive whereas non-lethal parasite leads to low frequencies of Treg cells seldom impede immune response that allow the parasite to get self-resolved.

Topics: Animals; CD4 Antigens; Cytokines; Female; Flow Cytometry; Forkhead Transcription Factors; Humans; Inducible T-Cell Co-Stimulator Protein; Interleukin-10; Malaria; Mice; Mice, Inbred BALB C; Parasitemia; Peptide Fragments; Plasmodium berghei; Plasmodium chabaudi; Plasmodium yoelii; Specific Pathogen-Free Organisms; Spleen; T-Lymphocytes, Regulatory