ccx282-b and Celiac-Disease

Celiac disease (CD) is an autoimmune enteropathy triggered by gluten. Gluten-free diets can be challenging because of their restrictive nature, inadvertent cross-contaminations, and the high cost of gluten-free food. Novel nondietary therapies are at the preclinical stage, clinical trial phase, or have already been developed for other indications and are now being applied to CD. These therapies include enzymatic gluten degradation, binding and sequestration of gluten, restoration of epithelial tight junction barrier function, inhibition of tissue transglutaminase-mediated potentiation of gliadin oligopeptide immunogenicity or of human leukocyte antigen-mediated gliadin presentation, induction of tolerance to gluten, and antiinflammatory interventions.

Topics: Autoimmunity; Bifidobacterium longum subspecies infantis; Celiac Disease; Combined Modality Therapy; Diet, Gluten-Free; HLA-DQ Antigens; Humans; Immunologic Factors; Lactococcus lactis; Molecular Targeted Therapy; Oligopeptides; Pancrelipase; Peptide Hydrolases; Probiotics; Sulfonamides

Celiac disease is an autoimmune enteropathy triggered by the ingestion of gluten, characterized by immune responses toward gluten constituents and the autoantigen transglutaminase 2. The only current treatment available for celiac disease is a gluten-free diet, however there are a plethora of therapies in development for the treatment of celiac disease (e.g. vaccine), management of symptoms while consuming gluten (e.g. Necator americanus) or adjuvant therapies in conjunction with the gluten-free diet (e.g. larazotide acetate). Current approaches in development target barrier function, immune responses, detoxifying gluten or sequestering gluten. Developing therapies include those targeting environmental factors, such as the microbiota or proteases.

Topics: Ancylostomatoidea; Animals; Celiac Disease; Diet, Gluten-Free; Elafin; Enzyme Therapy; Glutens; GTP-Binding Proteins; HLA Antigens; Humans; Models, Biological; Probiotics; Protein Glutamine gamma Glutamyltransferase 2; Sulfonamides; T-Lymphocytes; Transglutaminases