cathepsin-g and Kidney-Diseases

cathepsin-g has been researched along with Kidney-Diseases* in 1 studies

Other Studies

1 other study(ies) available for cathepsin-g and Kidney-Diseases

ArticleYear
The human neutrophil serine proteinases, elastase and cathepsin G, can mediate glomerular injury in vivo.
    The Journal of experimental medicine, 1988, Sep-01, Volume: 168, Issue:3

    We infused microgram quantities of active or inactive PMN elastase and cathepsin G into the renal arteries of rats. Both active and inactive elastase localized to the glomerular capillary wall equally, and in amounts that could be achieved physiologically in GN. However, elastase-perfused rats developed marked proteinuria (196 +/- 32 mg/24 h) compared with control rats receiving inactive elastase (19 +/- 2 mg/24 h, p less than 0.005). Similar results were seen with active and inactive cathepsin G. Neither elastase nor cathepsin G infusion was associated with histologic evidence of glomerular injury. We conclude that the PMN neutral serine proteinases elastase and cathepsin G can mediate marked changes in glomerular permeability in vivo due to their proteolytic activity, and thus, may contribute to the proteinuria observed in PMN-dependent models of GN.

    Topics: Animals; Cathepsin G; Cathepsins; Fluorescent Antibody Technique; Kidney Diseases; Kidney Glomerulus; Neutrophils; Pancreatic Elastase; Proteinuria; Rats; Serine Endopeptidases

1988