casticin has been researched along with Bronchial-Spasm* in 1 studies
1 other study(ies) available for casticin and Bronchial-Spasm
| Article | Year |
|---|---|
Tracheospasmolytic activity of viteosin-A and vitexicarpin isolated from vitex trifolia.
The n-hexane extract that has shown activity in the tracheospasmolytic bioassay was fractionated by solvent extraction and from the major active fraction two compounds were isolated and identified as viteosin-A and vitexicarpin. These compounds blocked spontaneous contraction of isolated male guinea pig trachea induced by histamine; however only vitexicarpin was active in a model using sensitized guinea pig trachea stimulated by ovalbumin up to minimum dose of 1.3 x 10(-5) M. The result suggests that vitexicarpin is able to block effects of histamine released from sensitized mast cells possibly by stabilizing the mast cells membrane function. Topics: Animals; Bronchial Spasm; Dose-Response Relationship, Drug; Flavonoids; Guinea Pigs; Histamine; Isoquinolines; Male; Ovalbumin; Phytotherapy; Plant Extracts; Plant Leaves; Trachea; Vitex | 2002 |