casein-kinase-ii and Progeria

casein-kinase-ii has been researched along with Progeria* in 1 studies

Other Studies

1 other study(ies) available for casein-kinase-ii and Progeria

Article	Year
Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model. Science advances, 2019, Volume: 5, Issue:3 Defective nuclear lamina protein lamin A is associated with premature aging. Casein kinase 2 (CK2) binds the nuclear lamina, and inhibiting CK2 activity induces cellular senescence in cancer cells. Thus, it is feasible that lamin A and CK2 may cooperate in the aging process. Nuclear CK2 localization relies on lamin A and the lamin A carboxyl terminus physically interacts with the CK2α catalytic core and inhibits its kinase activity. Loss of lamin A in Topics: Aging; Animals; Casein Kinase II; Cell Nucleus; Cellular Senescence; Disease Models, Animal; DNA Damage; DNA Repair; Fibroblasts; Humans; Lamin Type A; Membrane Proteins; Metalloendopeptidases; Mice; Mice, Knockout; Progeria; Protein Binding; Spermidine	2019

Article

Year

Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model.

Science advances, 2019, Volume: 5, Issue:3

Defective nuclear lamina protein lamin A is associated with premature aging. Casein kinase 2 (CK2) binds the nuclear lamina, and inhibiting CK2 activity induces cellular senescence in cancer cells. Thus, it is feasible that lamin A and CK2 may cooperate in the aging process. Nuclear CK2 localization relies on lamin A and the lamin A carboxyl terminus physically interacts with the CK2α catalytic core and inhibits its kinase activity. Loss of lamin A in

Topics: Aging; Animals; Casein Kinase II; Cell Nucleus; Cellular Senescence; Disease Models, Animal; DNA Damage; DNA Repair; Fibroblasts; Humans; Lamin Type A; Membrane Proteins; Metalloendopeptidases; Mice; Mice, Knockout; Progeria; Protein Binding; Spermidine

2019