casein-kinase-ii and Hypersensitivity

The quality of the adaptive immune response depends on the differentiation of distinct CD4(+) helper T cell subsets, and the magnitude of an immune response is controlled by CD4(+)Foxp3(+) regulatory T cells (Treg cells). However, how a tissue- and cell type-specific suppressor program of Treg cells is mechanistically orchestrated has remained largely unexplored. Through the use of Treg cell-specific gene targeting, we found that the suppression of allergic immune responses in the lungs mediated by T helper type 2 (TH2) cells was dependent on the activity of the protein kinase CK2. Genetic ablation of the β-subunit of CK2 specifically in Treg cells resulted in the proliferation of a hitherto-unexplored ILT3(+) Treg cell subpopulation that was unable to control the maturation of IRF4(+)PD-L2(+) dendritic cells required for the development of TH2 responses in vivo.

Topics: Animals; Casein Kinase II; CD4-Positive T-Lymphocytes; Cell Differentiation; Cell Growth Processes; Cell Line; Dendritic Cells; Forkhead Transcription Factors; Humans; Hypersensitivity; Interferon Regulatory Factors; Leukocytes, Mononuclear; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Receptors, Cell Surface; T-Lymphocytes, Regulatory; Th2 Cells