casein-kinase-ii and Ciliopathies

casein-kinase-ii has been researched along with Ciliopathies* in 1 studies

Other Studies

1 other study(ies) available for casein-kinase-ii and Ciliopathies

Article	Year
A complex of distal appendage-associated kinases linked to human disease regulates ciliary trafficking and stability. Proceedings of the National Academy of Sciences of the United States of America, 2021, 04-20, Volume: 118, Issue:16 Cilia biogenesis is a complex, multistep process involving the coordination of multiple cellular trafficking pathways. Despite the importance of ciliogenesis in mediating the cellular response to cues from the microenvironment, we have only a limited understanding of the regulation of cilium assembly. We previously identified Tau tubulin kinase 2 (TTBK2) as a key regulator of ciliogenesis. Here, using CRISPR kinome and biotin identification screening, we identify the CK2 catalytic subunit CSNK2A1 as an important modulator of TTBK2 function in cilia trafficking. Superresolution microscopy reveals that CSNK2A1 is a centrosomal protein concentrated at the mother centriole and associated with the distal appendages. Topics: Animals; Casein Kinase II; Cell Line; Centrioles; Cilia; Ciliopathies; Hedgehog Proteins; HEK293 Cells; Humans; Mice; Neurodevelopmental Disorders; Protein Serine-Threonine Kinases	2021

Article

Year

A complex of distal appendage-associated kinases linked to human disease regulates ciliary trafficking and stability.

Proceedings of the National Academy of Sciences of the United States of America, 2021, 04-20, Volume: 118, Issue:16

Cilia biogenesis is a complex, multistep process involving the coordination of multiple cellular trafficking pathways. Despite the importance of ciliogenesis in mediating the cellular response to cues from the microenvironment, we have only a limited understanding of the regulation of cilium assembly. We previously identified Tau tubulin kinase 2 (TTBK2) as a key regulator of ciliogenesis. Here, using CRISPR kinome and biotin identification screening, we identify the CK2 catalytic subunit CSNK2A1 as an important modulator of TTBK2 function in cilia trafficking. Superresolution microscopy reveals that CSNK2A1 is a centrosomal protein concentrated at the mother centriole and associated with the distal appendages.

Topics: Animals; Casein Kinase II; Cell Line; Centrioles; Cilia; Ciliopathies; Hedgehog Proteins; HEK293 Cells; Humans; Mice; Neurodevelopmental Disorders; Protein Serine-Threonine Kinases

2021