casein-hydrolysate and Liver-Diseases

Hyperglycemia-induced oxidative stress can cause liver damage in diabetes, and protein hydrolysates with antidiabetic and antioxidant properties are emerging as a potential therapy. In this study, protective effects of casein hydrolysates against live oxidative damage in streptozotocin/high-fat-induced diabetic rats were studied and potentially bioactive peptides were explored by an integrated approach of differential peptide and in silico analysis. Results showed that different casein hydrolysates significantly alleviated liver oxidative damage (

Topics: Animals; Caseins; Diabetes Mellitus, Experimental; Diet, High-Fat; Female; Humans; Kelch-Like ECH-Associated Protein 1; Liver Diseases; Male; NF-E2-Related Factor 2; Oxidative Stress; Peptides; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species

A 10-day-old male neonate was admitted with bilious vomiting and gross hematochezia. Peripheral eosinophilia, delayed positive skin prick test to artificial milk, and elevated eosinophil cationic protein levels suggested cow's milk allergy. Fluid infusion with prohibition of oral intake improved the digestive symptoms. Breast-feeding was resumed on hospital day 3 and only casein hydrolysate formula was fed from day 7 onward. Nevertheless, eosinophilia and elevated transaminase levels developed on day 14. Liver dysfunction associated with casein hydrolysate formula was suspected and the infant was transferred to soy formula. Eosinophil counts decreased and transaminase levels were normalized on day 19. A cow's milk protein-specific lymphocyte proliferation test was positive for alpha-casein, beta-lactoglobulin, and bovine serum albumin, indicating sensitization of T cells to cow's milk proteins. These observations suggest that careful attention should be paid to liver dysfunction in non-immunoglobulin E-mediated cow's milk allergy, even when hypoallergenic formula is used.

Topics: Caseins; Eosinophilia; Humans; Immunoglobulin E; Infant Formula; Infant, Newborn; Liver Diseases; Male; Milk Hypersensitivity

Topics: Amyloidosis; Animals; Bicarbonates; Caseins; Gelatin; Injections; Injections, Intraperitoneal; Injections, Subcutaneous; Liver Diseases; Mice; Pathology; Research; Spleen

Topics: Animals; Blood Proteins; Caseins; Dogs; Infusions, Intravenous; Infusions, Parenteral; Liver Diseases; Protein Hydrolysates