caryophyllene-oxide and Ovarian-Neoplasms

Bioassay guided fractionation of Cinnamon tamala leaf extracts yielded bornyl acetate (1), caryophylene oxide (2), p-coumaric acid (3) and vanillic acid (4) using A-2780 human ovarian cancer cell lines. The structures of the isolated compounds were confirmed through spectroscopic techniques (EIMS, (1)H and (13)C NMR). Compound 1 exhibited highest cytotoxicity with 90.16 ± 1.06% inhibition (IC50=5.30 x 10(-4) mg/ml) followed by compound 2 (84.40±1.53% inhibition; IC50=8.94 x 10(-3)mg/ml), while compounds 3 and 4 were inactive in the bioassay.

Topics: Animals; Antineoplastic Agents, Phytogenic; Camphanes; Carcinoma; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cinnamomum; Coumaric Acids; Cricetinae; Drug Screening Assays, Antitumor; Female; Humans; Ovarian Neoplasms; Plant Extracts; Plant Leaves; Polycyclic Sesquiterpenes; Propionates; Sesquiterpenes; Vanillic Acid