caryophyllene-oxide and Edema

Caryophyllene oxide was isolated from an unsaponified petroleum ether extract of the bark of Annona squamosa and studied for its analgesic and anti-inflammatory activity. Caryophyllene oxide at the doses of 12.5 and 25mg/kg body wt. and unsaponified petroleum ether extract at a dose of 50mg/kg body wt. showed significant central as well as peripheral analgesic, along with anti-inflammatory, activity. These activities of caryophyllene oxide were comparable with the standard drug used in the respective experiments.

Topics: Acetic Acid; Analgesics; Animals; Annona; Anti-Inflammatory Agents; Carrageenan; Edema; Female; Hot Temperature; Male; Mice; Pain; Phytotherapy; Plant Bark; Plant Extracts; Polycyclic Sesquiterpenes; Rats; Rats, Wistar; Sesquiterpenes