Page last updated: 2024-10-24

carvedilol and Mitral Valve Insufficiency

carvedilol has been researched along with Mitral Valve Insufficiency in 14 studies

Mitral Valve Insufficiency: Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation.

Research Excerpts

ExcerptRelevanceReference
"We and others have previously shown that carvedilol improves left ventricular (LV) function and symptoms in chronic heart failure."9.09Effects of carvedilol on left ventricular mass, chamber geometry, and mitral regurgitation in chronic heart failure. ( Abraham, WT; Bristow, MR; Gilbert, EM; Gill, EA; Larrain, JR; Lowes, BD; Robertson, AD, 1999)
"In patients with chronic heart failure, the use of carvedilol therapy induces clinical and hemodynamic improvement."9.09Beta-blockade therapy in chronic heart failure: diastolic function and mitral regurgitation improvement by carvedilol. ( Capomolla, S; Caporotondi, A; Cobelli, F; Febo, O; Gnemmi, M; Mortara, A; Opasich, C; Pinna, GD; Riccardi, G, 2000)
"We and others have previously shown that carvedilol improves left ventricular (LV) function and symptoms in chronic heart failure."5.09Effects of carvedilol on left ventricular mass, chamber geometry, and mitral regurgitation in chronic heart failure. ( Abraham, WT; Bristow, MR; Gilbert, EM; Gill, EA; Larrain, JR; Lowes, BD; Robertson, AD, 1999)
"In patients with chronic heart failure, the use of carvedilol therapy induces clinical and hemodynamic improvement."5.09Beta-blockade therapy in chronic heart failure: diastolic function and mitral regurgitation improvement by carvedilol. ( Capomolla, S; Caporotondi, A; Cobelli, F; Febo, O; Gnemmi, M; Mortara, A; Opasich, C; Pinna, GD; Riccardi, G, 2000)
" Demographic, physical examination and diagnostic imaging findings, blood pressure (BP), administration details and outcome were obtained from medical records of dogs receiving carvedilol for preclinical CVD."3.78Retrospective review of carvedilol administration in 38 dogs with preclinical chronic valvular heart disease. ( Boggess, MM; Gordon, SG; Hariu, CD; Miller, MW; Saunders, AB, 2012)
"Carvedilol was started in week 2 post MR induction and given for 23 to 35 weeks in the β-blockade group."1.39Effects of early, late, and long-term nonselective β-blockade on left ventricular remodeling, function, and survival in chronic organic mitral regurgitation. ( Davidson, WR; Gao, Z; Pu, DK; Pu, M, 2013)
"Recently described Takotsubo syndrome is characterized by acute reversible left ventricular dysfunction with apical ballooning in the absence of coronary artery disease, and with chest pain and electrocardiographic changes mimicking acute anterior myocardial infarction, but with minimal release of myocardial enzymes."1.35Takotsubo syndrome after cardiac surgery. ( Ghosh, P; Kogan, A; Raanani, E; Schwammenthal, E, 2008)
" Thus, it is necessary to titrate the dosage of carvedilol, it should be initiated at less than 0."1.31Cardiovascular and renal effects of carvedilol in dogs with heart failure. ( Ishikawa, Y; Sasaki, T; Uechi, M; Ueno, K; Yamamoto, T, 2002)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.14)18.2507
2000's7 (50.00)29.6817
2010's5 (35.71)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
McCutcheon, K1
Dickens, C1
van Pelt, J1
Dix-Peek, T1
Grinter, S1
McCutcheon, L1
Patel, A1
Hale, M1
Tsabedze, N1
Vachiat, A1
Zachariah, D1
Duarte, R1
Janssens, S1
Manga, P1
Tanaka, S1
Imamura, T1
Ueno, H1
Kinugawa, K1
Pu, M1
Gao, Z1
Pu, DK1
Davidson, WR1
Borer, JS1
Marcondes-Santos, M1
Mansur, AP1
Fragata, FS1
Strunz, CM1
Gordon, SG1
Saunders, AB1
Hariu, CD1
Boggess, MM1
Miller, MW1
Uechi, M1
Sasaki, T1
Ueno, K1
Yamamoto, T1
Ishikawa, Y1
Kotlyar, E1
Hayward, CS1
Keogh, AM1
Feneley, M1
Macdonald, PS1
Kogan, A1
Ghosh, P1
Schwammenthal, E1
Raanani, E1
Lowes, BD1
Gill, EA1
Abraham, WT1
Larrain, JR1
Robertson, AD1
Bristow, MR1
Gilbert, EM1
Eichhorn, EJ1
Grayburn, PA1
Capomolla, S1
Febo, O1
Gnemmi, M1
Riccardi, G1
Opasich, C1
Caporotondi, A1
Mortara, A1
Pinna, GD1
Cobelli, F1
Comin-Colet, J1
Sánchez-Corral, MA1
Manito, N1
Gómez-Hospital, JA1
Roca, J1
Fernández-Nofrerias, E1
Valdovinos, P1
Esplugas, E1
Nägele, H1
Schomburg, R1
Petersen, B1
Rödiger, W1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Beta-Blockade in Chronic Mitral Regurgitation: Moving From the Laboratory Experiment to Clinical Investigation[NCT00700947]Phase 127 participants (Actual)Interventional2007-10-31Terminated (stopped due to Funding terminated)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

6 trials available for carvedilol and Mitral Valve Insufficiency

ArticleYear
Dynamic Changes in the Molecular Signature of Adverse Left Ventricular Remodeling in Patients With Compensated and Decompensated Chronic Primary Mitral Regurgitation.
    Circulation. Heart failure, 2019, Volume: 12, Issue:9

    Topics: Adult; Cardiovascular Agents; Carvedilol; Chronic Disease; Gene Expression Profiling; Humans; Middle

2019
Effects of carvedilol on left ventricular mass, chamber geometry, and mitral regurgitation in chronic heart failure.
    The American journal of cardiology, 1999, Apr-15, Volume: 83, Issue:8

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Carbazoles; Carvedilol; Dou

1999
beta-blocker improvement in diastolic performance: the yin and yang of ventricular function changes.
    American heart journal, 2000, Volume: 139, Issue:4

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Carbazoles; Carvedilol; Diastole; Female; Heart Failure; H

2000
Beta-blockade therapy in chronic heart failure: diastolic function and mitral regurgitation improvement by carvedilol.
    American heart journal, 2000, Volume: 139, Issue:4

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Carbazoles; Carvedilol; Diastole; Echocardiography; Female

2000
Effect of carvedilol therapy on functional mitral regurgitation, ventricular remodeling, and contractility in patients with heart failure due to left ventricular systolic dysfunction.
    Transplantation proceedings, 2002, Volume: 34, Issue:1

    Topics: Adrenergic beta-Antagonists; Carbazoles; Carvedilol; Female; Follow-Up Studies; Heart Failure; Heart

2002
Dual chamber pacing in patients with severe heart failure on beta blocker and amiodarone treatment: preliminary results of a randomised study.
    Heart (British Cardiac Society), 2002, Volume: 87, Issue:6

    Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Carbazoles; Cardiac Pacing, Artific

2002

Other Studies

8 other studies available for carvedilol and Mitral Valve Insufficiency

ArticleYear
MitraClip or Ventricular Assist Device?
    International heart journal, 2020, Nov-28, Volume: 61, Issue:6

    Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Cardiac Resynchronization The

2020
Effects of early, late, and long-term nonselective β-blockade on left ventricular remodeling, function, and survival in chronic organic mitral regurgitation.
    Circulation. Heart failure, 2013, Volume: 6, Issue:4

    Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Carbazoles; Carvedilol; Chronic Disease; Echoc

2013
Mitral regurgitation: has another magic bullet bitten the dust?
    Circulation. Heart failure, 2013, Volume: 6, Issue:4

    Topics: Adrenergic beta-Antagonists; Animals; Carbazoles; Carvedilol; Mitral Valve Insufficiency; Propanolam

2013
Short-term follow-up of exercise training program and beta-blocker treatment on quality of life in dogs with naturally acquired chronic mitral valve disease.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2015, Volume: 48, Issue:10

    Topics: Adrenergic beta-Antagonists; Analysis of Variance; Animals; Carbazoles; Carvedilol; Dogs; Echocardio

2015
Retrospective review of carvedilol administration in 38 dogs with preclinical chronic valvular heart disease.
    Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology, 2012, Volume: 14, Issue:1

    Topics: Adrenergic beta-Antagonists; Aging; Animals; Carbazoles; Carvedilol; Chronic Disease; Dog Diseases;

2012
Cardiovascular and renal effects of carvedilol in dogs with heart failure.
    The Journal of veterinary medical science, 2002, Volume: 64, Issue:6

    Topics: Administration, Oral; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agoni

2002
The impact of baseline left ventricular size and mitral regurgitation on reverse left ventricular remodelling in response to carvedilol: size doesn't matter.
    Heart (British Cardiac Society), 2004, Volume: 90, Issue:7

    Topics: Adrenergic beta-Antagonists; Carbazoles; Cardiomyopathy, Dilated; Carvedilol; Chronic Disease; Echoc

2004
Takotsubo syndrome after cardiac surgery.
    The Annals of thoracic surgery, 2008, Volume: 85, Issue:4

    Topics: Bioprosthesis; Carbazoles; Cardiopulmonary Bypass; Carvedilol; Echocardiography, Transesophageal; El

2008