Page last updated: 2024-10-24

carvedilol and Heritable Pulmonary Arterial Hypertension

carvedilol has been researched along with Heritable Pulmonary Arterial Hypertension in 1 studies

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Grinnan, D1
Bogaard, HJ1
Grizzard, J1
Van Tassell, B1
Abbate, A1
DeWilde, C1
Priday, A1
Voelkel, NF1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pilot Study of the Safety and Efficacy of Carvedilol in Pulmonary Arterial Hypertension[NCT00964678]Phase 1/Phase 210 participants (Actual)Interventional2010-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Absolute Change in Right Ventricular Ejection Fraction

Change in right ventricular ejection fraction is measured by cardiac magnetic resonance imaging, using the method of disks with the reading radiologist being blinded to before and after images. Cardiac magnetic resonance imaging was done at baseline and 6 months only (NCT00964678)
Timeframe: baseline, 6 months

Intervention% RVEF (Mean)
Carvedilol10.4

Change in 6 Minute Walk Distance

(NCT00964678)
Timeframe: baseline and 6 months

Interventionfeet (Number)
Participant 1Participant 2Participant 3Participant 5Participant 6
Carvedilol4516035596

Change in Right Ventricular End Systolic Volume

right ventricular end systolic volume determined by MRI (NCT00964678)
Timeframe: baseline and 6 months

InterventionmL (Number)
Participant 1Participant 2Participant 3Participant 4Participant 5Participant 6
Carvedilol31456112725

Change in Tricuspid Annular Plane Systolic Excursion

Higher values indicate a better outcome. (NCT00964678)
Timeframe: baseline and 6 months

Interventioncentimeters (Number)
Participant 1Participant 2Participant 4Participant 5Participant 6
Carvedilol0.4-0.08-0.120.450.08

Trials

1 trial available for carvedilol and Heritable Pulmonary Arterial Hypertension

ArticleYear
Treatment of group I pulmonary arterial hypertension with carvedilol is safe.
    American journal of respiratory and critical care medicine, 2014, Jun-15, Volume: 189, Issue:12

    Topics: Adrenergic beta-Antagonists; Aged; Carbazoles; Carvedilol; Drug Administration Schedule; Familial Pr

2014