Page last updated: 2024-10-24

carvedilol and Cirrhosis

carvedilol has been researched along with Cirrhosis in 20 studies

Research Excerpts

ExcerptRelevanceReference
"To determine whether beta-blocker dose influences cardiac collagen turnover and the effects of spironolactone on cardiac collagen turnover in patients with heart failure."9.12Association of beta-blocker dose with serum procollagen concentrations and cardiac response to spironolactone in patients with heart failure. ( Camp, JR; Cavallari, LH; Groo, VL; Momary, KM; Stamos, TD; Viana, MA, 2007)
" • Carvedilol reduced biventricular TGFβ1-CTGF signaling, fibrosis, and apoptosis."7.81Carvedilol improves biventricular fibrosis and function in experimental pulmonary hypertension. ( Breitling, S; Friedberg, MK; Honjo, O; Kato, H; Kuebler, WM; Okumura, K; Sun, M, 2015)
"To investigate the effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction (MI)."7.74[Effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction]. ( Chen, H; Guo, CY; Li, HW; Li, ZZ; Shen, LH; Sun, T; Tang, CS, 2008)
"Carvedilol (20 mg/kg, bid) or vehicle was given to rats surviving a myocardial infarction (MI) 24 h (n = 409)."7.71Long-term effects of carvedilol on left ventricular function, remodeling, and expression of cardiac cytokines after large myocardial infarction in the rat. ( Adam, A; Liu, P; Parker, TG; Rouleau, JL; Sia, YT; Tsoporis, JN, 2002)
"Carvedilol was administered intraperitoneally to 8 week-old TO2 hamsters for 21 weeks at a dose of 11 mg/kg/day."5.33Carvedilol prevents myocardial fibrosis in hamsters. ( Ishii, T; Nanjo, S; Togane, Y; Yamazaki, J; Yoshikawa, K, 2006)
"To determine whether beta-blocker dose influences cardiac collagen turnover and the effects of spironolactone on cardiac collagen turnover in patients with heart failure."5.12Association of beta-blocker dose with serum procollagen concentrations and cardiac response to spironolactone in patients with heart failure. ( Camp, JR; Cavallari, LH; Groo, VL; Momary, KM; Stamos, TD; Viana, MA, 2007)
" • Carvedilol reduced biventricular TGFβ1-CTGF signaling, fibrosis, and apoptosis."3.81Carvedilol improves biventricular fibrosis and function in experimental pulmonary hypertension. ( Breitling, S; Friedberg, MK; Honjo, O; Kato, H; Kuebler, WM; Okumura, K; Sun, M, 2015)
"High-dose carvedilol alleviated LV remodelling and diastolic dysfunction following SVR accompanying with reduction in myocardial fibrosis."3.76Carvedilol may alleviate late cardiac remodelling following surgical ventricular restoration. ( Ikeda, T; Komeda, M; Marui, A; Muranaka, H; Nishina, T; Tsukashita, M; Wang, J; Yoshikawa, E, 2010)
"To investigate the effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction (MI)."3.74[Effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction]. ( Chen, H; Guo, CY; Li, HW; Li, ZZ; Shen, LH; Sun, T; Tang, CS, 2008)
"Carvedilol (20 mg/kg, bid) or vehicle was given to rats surviving a myocardial infarction (MI) 24 h (n = 409)."3.71Long-term effects of carvedilol on left ventricular function, remodeling, and expression of cardiac cytokines after large myocardial infarction in the rat. ( Adam, A; Liu, P; Parker, TG; Rouleau, JL; Sia, YT; Tsoporis, JN, 2002)
" The cardioprotective properties of carvedilol, a vasodilating beta-adrenoceptor-blocking agent, were studied in a rat model of dilated cardiomyopathy after autoimmune myocarditis."3.71Effects of carvedilol on cardiac function and cardiac adrenergic neuronal damage in rats with dilated cardiomyopathy. ( Aizawa, Y; Ashino, H; Fuse, K; Kodama, M; Nakazawa, M; Takahashi, T; Tanabe, N; Tazawa, S; Wahed, MI; Watanabe, K, 2002)
"Carvedilol appears to be a potentially viable option for treating portal hypertension."2.42Evaluation of carvedilol for the treatment of portal hypertension. ( Hemstreet, BA, 2004)
"Ascites is associated with a high risk of death."1.72Incidence of, Risk Factors for, and Outcomes After Ascites in a Population-Based Cohort of Older Americans. ( Mazumder, N; Parikh, ND; Tapper, EB; Zhao, Z, 2022)
"Carvedilol was adiministered for 4 weeks starting at week 13."1.56Carvedilol Diminishes Cardiac Remodeling Induced by High-Fructose/High-Fat Diet in Mice via Enhancing Cardiac β-Arrestin2 Signaling. ( Ibrahim, IAAE; Ibrahim, WS; Mahmoud, AAA; Mahmoud, MF, 2020)
"Treatment with carvedilol or amlodipine completely prevented left ventricular collagen deposition and morphometric alterations in aorta."1.46Effects of carvedilol or amlodipine on target organ damage in L-NAME hypertensive rats: their relationship with blood pressure variability. ( Berg, G; Bertera, FM; Carranza, A; Chiappetta, DA; Del Mauro, JS; Donato, M; Fernandez Machulsky, N; Gelpi, RJ; González, GE; Gorzalczany, SB; Höcht, C; Morales, C; Morettón, MA; Prince, PD; Taira, CA, 2017)
"Carvedilol was administered intraperitoneally to 8 week-old TO2 hamsters for 21 weeks at a dose of 11 mg/kg/day."1.33Carvedilol prevents myocardial fibrosis in hamsters. ( Ishii, T; Nanjo, S; Togane, Y; Yamazaki, J; Yoshikawa, K, 2006)
"2."1.31Renoprotective effects of carvedilol in hypertensive-stroke prone rats may involve inhibition of TGF beta expression. ( Barone, F; Brooks, DP; Campbell, WG; Contino, LC; Gygielko, E; Laping, NJ; Nelson, AH; Olson, BA; Wong, VY, 2001)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's10 (50.00)29.6817
2010's8 (40.00)24.3611
2020's2 (10.00)2.80

Authors

AuthorsStudies
Tapper, EB1
Zhao, Z1
Mazumder, N1
Parikh, ND1
Adachi, M1
Watanabe, M1
Kurata, Y1
Inoue, Y1
Notsu, T1
Yamamoto, K2
Horie, H1
Tanno, S1
Morita, M1
Miake, J1
Hamada, T1
Kuwabara, M1
Nakasone, N1
Ninomiya, H1
Tsuneto, M1
Shirayoshi, Y1
Yoshida, A1
Nishimura, M1
Hisatome, I1
Ibrahim, WS1
Ibrahim, IAAE1
Mahmoud, MF1
Mahmoud, AAA1
Del Mauro, JS1
Prince, PD1
Donato, M1
Fernandez Machulsky, N1
Morettón, MA1
González, GE1
Bertera, FM1
Carranza, A1
Gorzalczany, SB1
Chiappetta, DA1
Berg, G1
Morales, C1
Gelpi, RJ1
Taira, CA1
Höcht, C1
Zhu, JN1
Chen, R1
Fu, YH1
Lin, QX1
Huang, S1
Guo, LL1
Zhang, MZ1
Deng, CY1
Zou, X1
Zhong, SL1
Yang, M1
Zhuang, J1
Yu, XY1
Shan, ZX1
Okumura, K1
Kato, H1
Honjo, O1
Breitling, S1
Kuebler, WM1
Sun, M1
Friedberg, MK1
Chen, YL2
Chung, SY1
Chai, HT1
Chen, CH1
Liu, CF1
Huang, TH1
Zhen, YY1
Sung, PH1
Sun, CK1
Chua, S1
Lu, HI1
Lee, FY1
Sheu, JJ1
Yip, HK1
Wang, K1
Lu, D1
Zhang, B1
Wang, S1
Liu, Q1
Zhang, Q1
Geng, J1
Shan, Q1
Sun, T1
Shen, LH1
Chen, H1
Li, HW1
Guo, CY1
Li, ZZ1
Tang, CS1
Yoshikawa, E1
Marui, A1
Tsukashita, M1
Nishina, T1
Wang, J1
Muranaka, H1
Ikeda, T1
Komeda, M1
Elnakish, MT1
Hassona, MD1
Alhaj, MA1
Moldovan, L1
Janssen, PM1
Khan, M1
Hassanain, HH1
Hemstreet, BA1
Watanabe, K2
Yaoita, H1
Ogawa, K1
Oikawa, M1
Maehara, K1
Maruyama, Y1
Nanjo, S1
Yamazaki, J1
Yoshikawa, K1
Ishii, T1
Togane, Y1
Tylicki, L1
Biedunkiewicz, B1
Chamienia, A1
Wojnarowski, K1
Zdrojewski, Z1
Aleksandrowicz, E1
Lysiak-Szydlowska, W1
Rutkowski, B1
Cavallari, LH1
Momary, KM1
Groo, VL1
Viana, MA1
Camp, JR1
Stamos, TD1
Wong, VY1
Laping, NJ1
Nelson, AH1
Contino, LC1
Olson, BA1
Gygielko, E1
Campbell, WG1
Barone, F1
Brooks, DP1
Briest, W1
Hölzl, A1
Rassler, B1
Deten, A1
Leicht, M1
Baba, HA1
Zimmer, HG1
Sia, YT1
Parker, TG1
Tsoporis, JN1
Liu, P1
Adam, A1
Rouleau, JL1
Takahashi, T1
Nakazawa, M1
Wahed, MI1
Fuse, K1
Tanabe, N1
Kodama, M1
Aizawa, Y1
Ashino, H1
Tazawa, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Renal Transplant Injury and the Renin-Angiotensin System in Kids (RETASK)[NCT03317925]29 participants (Actual)Observational2014-07-16Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for carvedilol and Cirrhosis

ArticleYear
Evaluation of carvedilol for the treatment of portal hypertension.
    Pharmacotherapy, 2004, Volume: 24, Issue:1

    Topics: Adrenergic Antagonists; Carbazoles; Carvedilol; Esophageal and Gastric Varices; Fibrosis; Humans; Hy

2004

Trials

2 trials available for carvedilol and Cirrhosis

ArticleYear
Renal allograft protection with angiotensin II type 1 receptor antagonists.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2007, Volume: 7, Issue:1

    Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Biomarkers; Carbazoles; Carvedilol; Cross-Over Studi

2007
Association of beta-blocker dose with serum procollagen concentrations and cardiac response to spironolactone in patients with heart failure.
    Pharmacotherapy, 2007, Volume: 27, Issue:6

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Carbazoles; Carvedilol; Diuretics; Dose-Response

2007

Other Studies

17 other studies available for carvedilol and Cirrhosis

ArticleYear
Incidence of, Risk Factors for, and Outcomes After Ascites in a Population-Based Cohort of Older Americans.
    Digestive diseases and sciences, 2022, Volume: 67, Issue:11

    Topics: Aged; Anticoagulants; Antiviral Agents; Ascites; Atorvastatin; Carvedilol; Diuretics; Fibrosis; Huma

2022
β-Adrenergic Blocker, Carvedilol, Abolishes Ameliorating Actions of Adipose-Derived Stem Cell Sheets on Cardiac Dysfunction and Remodeling After Myocardial Infarction.
    Circulation journal : official journal of the Japanese Circulation Society, 2019, 10-25, Volume: 83, Issue:11

    Topics: Adrenergic beta-Antagonists; Animals; Carvedilol; Cell Hypoxia; Cells, Cultured; Disease Models, Ani

2019
Carvedilol Diminishes Cardiac Remodeling Induced by High-Fructose/High-Fat Diet in Mice via Enhancing Cardiac β-Arrestin2 Signaling.
    Journal of cardiovascular pharmacology and therapeutics, 2020, Volume: 25, Issue:4

    Topics: Animals; beta-Arrestin 2; Cardiomegaly; Carvedilol; Cytokines; Diet, High-Fat; Dietary Sugars; Disea

2020
Effects of carvedilol or amlodipine on target organ damage in L-NAME hypertensive rats: their relationship with blood pressure variability.
    Journal of the American Society of Hypertension : JASH, 2017, Volume: 11, Issue:4

    Topics: Amlodipine; Animals; Antihypertensive Agents; Aorta; Biomarkers; Blood Pressure; Blood Pressure Dete

2017
Smad3 inactivation and MiR-29b upregulation mediate the effect of carvedilol on attenuating the acute myocardium infarction-induced myocardial fibrosis in rat.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Animals; Carbazoles; Cardiotonic Agents; Carvedilol; Down-Regulation; Fibroblasts; Fibrosis; Heart;

2013
Carvedilol improves biventricular fibrosis and function in experimental pulmonary hypertension.
    Journal of molecular medicine (Berlin, Germany), 2015, Volume: 93, Issue:6

    Topics: Animals; Antihypertensive Agents; Carbazoles; Carvedilol; Connective Tissue Growth Factor; Fibrosis;

2015
Early Administration of Carvedilol Protected against Doxorubicin-Induced Cardiomyopathy.
    The Journal of pharmacology and experimental therapeutics, 2015, Volume: 355, Issue:3

    Topics: Adrenergic beta-Antagonists; Animals; Antibiotics, Antineoplastic; Biomarkers; Carbazoles; Cardiomyo

2015
Renal Denervation Attenuates Multi-Organ Fibrosis and Improves Vascular Remodeling in Rats with Transverse Aortic Constriction Induced Cardiomyopathy.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2016, Volume: 40, Issue:3-4

    Topics: Alanine Transaminase; Angiotensin II; Animals; Aorta; Blood Pressure; Carbazoles; Cardiomegaly; Card

2016
[Effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction].
    Zhonghua xin xue guan bing za zhi, 2008, Volume: 36, Issue:1

    Topics: Adrenergic beta-Antagonists; Animals; Carbazoles; Carvedilol; Collagen; Disease Models, Animal; Fibr

2008
Carvedilol may alleviate late cardiac remodelling following surgical ventricular restoration.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2010, Volume: 37, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Carbazoles; Cardiac Catheterization; Carvedilol; Drug Evaluati

2010
Rac-induced left ventricular dilation in thyroxin-treated ZmRacD transgenic mice: role of cardiomyocyte apoptosis and myocardial fibrosis.
    PloS one, 2012, Volume: 7, Issue:8

    Topics: Animals; Apoptosis; Blotting, Western; Carbazoles; Cardiomegaly; Cardiomyopathies; Carvedilol; Echoc

2012
Attenuated cardioprotection by ischemic preconditioning in coronary stenosed heart and its restoration by carvedilol.
    Cardiovascular research, 2006, Aug-01, Volume: 71, Issue:3

    Topics: Adrenergic beta-Antagonists; Animals; Carbazoles; Carvedilol; Coronary Stenosis; Drug Evaluation, Pr

2006
Carvedilol prevents myocardial fibrosis in hamsters.
    International heart journal, 2006, Volume: 47, Issue:4

    Topics: Adrenergic beta-Antagonists; Animals; Carbazoles; Carvedilol; Cricetinae; Disease Models, Animal; Ec

2006
Renoprotective effects of carvedilol in hypertensive-stroke prone rats may involve inhibition of TGF beta expression.
    British journal of pharmacology, 2001, Volume: 134, Issue:5

    Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Carbazoles; Carvedilol; Collagen Type I; Dieta

2001
Cardiac remodeling after long term norepinephrine treatment in rats.
    Cardiovascular research, 2001, Volume: 52, Issue:2

    Topics: Adrenergic Antagonists; Analysis of Variance; Animals; Blotting, Western; Calcium Channel Blockers;

2001
Long-term effects of carvedilol on left ventricular function, remodeling, and expression of cardiac cytokines after large myocardial infarction in the rat.
    Journal of cardiovascular pharmacology, 2002, Volume: 39, Issue:1

    Topics: Adrenergic beta-Antagonists; Animals; Carbazoles; Carvedilol; Cytokines; Fibrosis; Gas Chromatograph

2002
Effects of carvedilol on cardiac function and cardiac adrenergic neuronal damage in rats with dilated cardiomyopathy.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2002, Volume: 43, Issue:4

    Topics: 3-Iodobenzylguanidine; Adrenergic beta-Antagonists; Adrenergic Fibers; Animals; Autoimmune Diseases;

2002