carubicin and Skin-Neoplasms

The aim of the experiment was to study the effect of three specialized food rations on activity of superoxide dismutase (SOD) in tissues of rats with transplanted Walker's carcinosarcoma 256 exposed to carminomycin. It was shown that the three specialized rations were able to significantly modify the SOD activity in the tissues of the rats with Walker's carcinosarcoma 256 at the background of treatment with carminomycin. Thus, the ration enriched with copper and zinc salts and folic acid activated SOD in the animals of all the groups. Still, the effect was higher in the tumor-bearing animals and the rats treated with carminomycin i.e. under conditions of oxidative stress. The use of the ration enriched with sulfur-containing amino acids, sodium selenide and vitamin E led to decreasing of the efficiency of the fermentative dismutation of O2 in the healthy rats and marked activating of SOD in the tumor-bearing animals. The ration containing lyophilized vegetables and vitamin E provided a significant increase in the SOD activity in the healthy rats. However, its potential was not sufficient for overcoming the SOD inhibiting effect of the tumor growth.

Topics: Animal Feed; Animals; Carcinoma 256, Walker; Carubicin; Copper; Copper Sulfate; Folic Acid; Liver; Male; Neoplasm Transplantation; Rats; Skin Neoplasms; Superoxide Dismutase; Zinc

The state of the thiol-dependent systems i.e. concentration of the SH-groups, activity of glutathione reductase and glutathione-S-transferase, carminomycin antitumor and toxic effects was studied under conditions of tumor growth and carminomycin therapy with the use of prophylactic rations (PR) aimed at stimulating the cell thiol-dependent and antioxidant systems for decreasing the drug toxic action. It was shown that addition of sulfur-containing amino acids, selenium and vitamin E to the ration of healthy and tumor-bearing rats (Walker carcinosarcoma 256) induced a decrease in the level of the SH-groups in the liver just likely promoting efficient extrahepatic usage of glutathione. After administration of carminomycin a long with the PR use, the liver showed the thiol-preserving capacity evidenced by a decrease or complete elimination of the above effect of the ration. The use of PR resulted in a marked increase in the glutathione-S-transferase activity in cytosol and to a lesser extent in the liver microsomes. A regulating effect of the PR on the activity of glutathione reductase was observed: its inhibition in the healthy animals and stimulation after carminomycin administration in the heart of the healthy animals and the liver of the tumor-bearing animals.

Topics: alpha-Tocopherol; Amino Acids, Sulfur; Animals; Carcinoma 256, Walker; Carubicin; Daunorubicin; Food, Fortified; Inactivation, Metabolic; Liver; Male; Rats; Selenious Acid; Selenium; Skin Neoplasms; Sulfhydryl Compounds; Tocopherols; Vitamin E

The paper reports on a trial in which nitrosomethylurea (NMU) was compared with CCNU both in combination with vincristine and dactinomycin or the same combination with DTIC in the treatment of disseminated skin melanoma. The long-term results were statistically better in the groups with NMU than in that with CCNU while there was no statistical difference regarding the complete regression. A second trial compared NMU with CCNU in the treatment of small cell carcinoma in a regimen of combined chemo-radiotherapy. No statistical difference was to be noticed in regard to objective response and median live duration. In comparison with regimens including adriamycin the study showed an equal effectiveness of the two drugs. A third part deals with carminomycin therapy in metastatic soft tissue sarcomas and with the preventive role of postoperative 5-fluorouracil in gastric carcinoma and colo-rectal cancer.

Topics: Antineoplastic Agents; Carcinoma, Small Cell; Carubicin; Dacarbazine; Dactinomycin; Drug Therapy, Combination; Female; Humans; Lomustine; Lung Neoplasms; Male; Melanoma; Methylnitrosourea; Neoplasms; Sarcoma; Skin Neoplasms; Soft Tissue Neoplasms; Vincristine