carubicin and Sarcoma--Ewing

The therapeutic effect of carminomycin in various combinations with other antitumor drugs, i. e. vincristin, cyclophosphan, dactinomycin and metatrexate was studied in clinics on 18 children with wide-spread Juing sarcoma. Satisfactory direct effect was observed with the use of the above combinations in 47.0 per cent of the patients, which was evident from a decrease in the secondary tumor, disappearance of the pains and improvement of the general state of the patients.

Topics: Antibiotics, Antineoplastic; Bone Neoplasms; Carubicin; Child; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Humans; Neoplasm Metastasis; Pelvic Neoplasms; Sarcoma, Ewing; Time Factors

As a result of total-local irradiation of the lung combined with polychemotherapy in patients with solitary metastases to the lungs, a 3-year survival in children was 52.7 +/- 12.1%, after local irradiation of the lungs and chemotherapy 30 +/- 11.8% of the patients. Combined treatment was well tolerated by pediatric patients. The results of the study have shown that radiation therapy of metastases of Ewing's sarcoma to the lungs with simultaneous polychemotherapy does not disturb external respiratory function even in a later period, the clinical manifestations of lung radiation reactions were seldom observed.

Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Carubicin; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Gamma Rays; Humans; Lung Neoplasms; Melphalan; Methotrexate; Orotic Acid; Prednisolone; Radiotherapy Dosage; Sarcoma, Ewing; Time Factors; Vincristine

The results of the treatment of the prevalent form of Ewing's sarcoma in 85 children aged 3 to 16 years with various methods are presented. 21 patients were subjected to monochemotherapy with sarcolysine or cyclophosphamide. 26 patients received monochemotherapy with sarcolysine or cyclophosphamide in combination with irradiation of the metastases. Polychemotherapy in combination with radiotherapy was applied to 38 patients. The polychemotherapy in combination with radiotherapy was applied to 38 patients. The polychemotherapy included cyclophosphamide, vincristine, methotrexate, dactinomycin and carminomycin used in various combinations. The schemes of the polychemotherapy are presented. The best results were obtained with the use of the polychemotherapy in combination with radiotherapy: the index of the 3-year survival amounted to 38.5+/-14 per cent, while in the patients subjected to the monochemotherapy in combination with irradiation of the metastases it was equal to 3.8+/-3.7 per cent. After the monochemotherapy used alone all the children died by the 2nd year. It is concluded that patients with the prevalent form of Ewing's sarcoma should b subjected to systematic treatment. Polychemotherapy in combination with radiotherapy is shown to be promising.

Topics: Adolescent; Carubicin; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Drug Evaluation; Drug Therapy, Combination; Humans; Melphalan; Neoplasm Metastasis; Radiotherapy Dosage; Sarcoma, Ewing

The clinical ratio of T- and B-lymphocytes in the peripheral blood of patients with osteogenic sarcoma and Ewing's sarcoma was studied. Significant changes in the ratio of T- and B-cells was found in the patients in the stage of generalization with metastases to the bones and lungs. During the treatment with carminomycin the relative number of T-cells reached the values close to the normal. The total number of lymphocytes in the blood and the absolute content of T- and B-cells in some patients remained decreased for a long period of time.

Topics: Adolescent; Adult; B-Lymphocytes; Bone Neoplasms; Carubicin; Child; Child, Preschool; Daunorubicin; Humans; Leukocyte Count; Osteosarcoma; Rosette Formation; Sarcoma, Ewing; T-Lymphocytes; Time Factors