carubicin and Maxillary-Neoplasms

The authors analyze the efficacy of antitumor drugs deposited with cyanoacrylate adhesive solution in therapy of Stages III-IV maxillary tumors. Immediate and late results of therapy with these compositions of 21 patients evidence that such treatment is not associated with the wound or general toxic complications and that wounds may be managed without tampons. Deposition of the drug and its regulated elimination from the composition helps create a high concentration of the agent at the operation site where the tumor elements remained after surgery; this permits expecting better late results.

Topics: Adult; Aged; Animals; Bleomycin; Carubicin; Clinical Trials as Topic; Cyanoacrylates; Daunorubicin; Drug Evaluation, Preclinical; Drug Implants; Female; Humans; Male; Maxilla; Maxillary Neoplasms; Middle Aged; Postoperative Care; Rats

The experience of the Moscow Research Institute of Oncology named after P. A. Herzen with the treatment of 368 primary patients with malignant tumors of the upper jaw, and the analysis of the literature data allowed a formulation of basic tendencies in therapy of this affection. These include a wide use of the combination therapy with preoperative radiation treatment; an elaboration of some extended variants of surgical interventions; an improvement of radiation technics, use of drug therapy, mainly as regional chemotherapy associated with radiotherapy. Further elaboration of the early diagnostics is also of importance. Patients in whom malignant tumors of the upper jaw were detected should be treated in specialized oncological departments, specially equipped and having well-trained medical staff.

Topics: Carubicin; Cyclophosphamide; Drug Therapy, Combination; Fluorouracil; Humans; Maxillary Neoplasms; Methotrexate; Prospidium; Radioisotope Teletherapy; Vincristine