carubicin and Hemorrhage

The reserve potentialities of the hematopoietic tissue were studied on 216 albino noninbred rats with the use of various models of the hemopoiesis compensation and functional strain and morphofunctional methods 30 days after the treatment with carminomycin. It was shown that compensation potentialities of the bone marrow granulocytic fiber by the moment of the reduction of the quantitative and morphological composition of the white blood after the antibiotic treatment were characterized by complete depletion of the granulocytic capillary pool and decreased granulocyte reserve of the bone marrow. The treatment with the antibiotic resulted in a decreased erythropoietic reaction (as compared to the control) to the acute blood loss evident from suppressed activity of the bone marrow by the 24th--48th hour, decreased rates of the erythroid element proliferation, lower rates of the reticulocyte "washings" into the blood channel, decreased 24-hour production of the erythrocytes and a more pronounced decrease in the hemoglobin and erythrocyte levels in the early periods after the anemization. The blood loss had no significant effect on the proliferating activity of the granulocytic element of the bone marrow and induced no development of the posthemorrhagic leucocytosis. The reaction of the hemopoietic thrombocytic growing fiber to the anemic stress in the experimental animals was not adequate. It was characterized by the development of pronounced thrombocytopenia and impairment of normal thrombocyte formation in the bone marrow.

Topics: Animals; Blood Cells; Blood Platelets; Carubicin; Daunorubicin; Erythrocytes; Granulocytes; Hematopoiesis; Hematopoietic System; Hemorrhage; Male; Rats; Time Factors