carubicin and Drug-Hypersensitivity

The antitumor activity and effect on immunogenesis of rubomycin and carminomycin combinations with levamisole were studied comparatively. It was found that levamisole administered after carminomycin increased the intensity of delayed hypersensitivity in mice and only partially reduced immunoreactivity of the animals estimated by the number of antibody-forming cells in the spleen. No such effect was observed after injections of rubomycin. The antitumor effect of the combinations of the antibiotics wit levamisole was studied in experimental transplantable mouse lymphosarcoma L10-1. The use of rubomycin or carminomycin in combination with levamisole increased the survival of the animals and sometimes resulted in complete resolution of the tumors. No such effect was observed in treatment of the animals with the drugs alone. The data are indicative of a possible use of levamisole in combination with antitumor antibiotics in immunochemotherapy of tumors.

Topics: Animals; Antibody Formation; Carubicin; Daunorubicin; Dose-Response Relationship, Immunologic; Drug Combinations; Drug Evaluation, Preclinical; Drug Hypersensitivity; Hypersensitivity, Delayed; Immunity, Cellular; Levamisole; Lymphoma, Non-Hodgkin; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental