carprofen has been researched along with Tuberculosis, Multidrug-Resistant in 1 studies
carprofen: RN given refers to cpd without isomeric designation
carprofen : Propanoic acid in which one of the methylene hydrogens is substituted by a 6-chloro-9H-carbazol-2-yl group. A non-steroidal anti-inflammatory drug, it is no longer used in human medicine but is still used for treatment of arthritis in elderly dogs.
Tuberculosis, Multidrug-Resistant: Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Carprofen was found to be a bactericidal drug that inhibited mycobacterial drug efflux mechanisms." | 5.56 | Carprofen elicits pleiotropic mechanisms of bactericidal action with the potential to reverse antimicrobial drug resistance in tuberculosis. ( Bhakta, S; Chapman, E; Chrzastek, A; Evangelopoulos, D; Hailes, HC; Hanrath, A; Lipman, M; Maitra, A; Martin, LT; McHugh, TD; Waddell, SJ, 2020) |
| "Carprofen was found to be a bactericidal drug that inhibited mycobacterial drug efflux mechanisms." | 1.56 | Carprofen elicits pleiotropic mechanisms of bactericidal action with the potential to reverse antimicrobial drug resistance in tuberculosis. ( Bhakta, S; Chapman, E; Chrzastek, A; Evangelopoulos, D; Hailes, HC; Hanrath, A; Lipman, M; Maitra, A; Martin, LT; McHugh, TD; Waddell, SJ, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maitra, A | 1 |
| Evangelopoulos, D | 1 |
| Chrzastek, A | 1 |
| Martin, LT | 1 |
| Hanrath, A | 1 |
| Chapman, E | 1 |
| Hailes, HC | 1 |
| Lipman, M | 1 |
| McHugh, TD | 1 |
| Waddell, SJ | 1 |
| Bhakta, S | 1 |
1 other study available for carprofen and Tuberculosis, Multidrug-Resistant
| Article | Year |
|---|---|
Carprofen elicits pleiotropic mechanisms of bactericidal action with the potential to reverse antimicrobial drug resistance in tuberculosis.
Topics: Antitubercular Agents; Carbazoles; Drug Resistance, Microbial; Humans; Mycobacterium tuberculosis; T | 2020 |