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carprofen and Synovitis

carprofen has been researched along with Synovitis in 8 studies

carprofen: RN given refers to cpd without isomeric designation
carprofen : Propanoic acid in which one of the methylene hydrogens is substituted by a 6-chloro-9H-carbazol-2-yl group. A non-steroidal anti-inflammatory drug, it is no longer used in human medicine but is still used for treatment of arthritis in elderly dogs.

Synovitis: Inflammation of the SYNOVIAL MEMBRANE.

Research Excerpts

ExcerptRelevanceReference
"To investigate the ability of a proprietary antagonist of E-type prostanoid receptor (EP) 4, grapiprant, and carprofen to attenuate lameness attributable to urate-induced synovitis in dogs."9.30Comparison of two inhibitors of E-type prostanoid receptor four and carprofen in dogs with experimentally induced acute synovitis. ( Budsberg, SC; Kleine, SA; Norton, MM; Sandberg, GS, 2019)
"A randomized, placebo-controlled, four-period cross-over laboratory study involving eight dogs was conducted to confirm the effective analgesic dose of firocoxib, a selective COX-2 inhibitor, in a synovitis model of arthritis."9.13Comparison of the effects of firocoxib, carprofen and vedaprofen in a sodium urate crystal induced synovitis model of arthritis in dogs. ( Hanson, PD; Hazewinkel, HA; Pollmeier, M; Theyse, LF; van den Brom, WE, 2008)
"This positive-control study evaluated the efficacy of firocoxib versus carprofen, deracoxib, and meloxicam for the prevention of pain and inflammation in a urate crystal synovitis model of lameness."9.12Firocoxib efficacy preventing urate-induced synovitis, pain, and inflammation in dogs. ( Drag, M; Hanson, PD; Kunkle, BN; Romano, D, 2007)
"To compare the analgesic and anti-inflammatory effect of single doses of carprofen, etodolac, meloxicam, and butorphanol in dogs with induced acute synovitis (acute pain model) via kinetic gait analysis and orthopedic evaluation and examine measurement of serum C-reactive protein (CRP) concentration as an indicator of treatment efficacy."7.72Effect of carprofen, etodolac, meloxicam, or butorphanol in dogs with induced acute synovitis. ( Borer, LR; Peel, JE; Schawalder, P; Seewald, W; Spreng, DE, 2003)
"Synovitis was induced in 1 stifle joint during each treatment by intra-articular injection of sodium urate (SU)."6.94Comparison of the effects on lameness of orally administered acetaminophen-codeine and carprofen in dogs with experimentally induced synovitis. ( Budsberg, SC; Kleine, SA; Norton, MM; Papich, MG; Sandberg, GS, 2020)
"Carprofen was also somewhat effective in attenuating the severity of urate-induced synovitis but to a lesser degree than the medium dose of deracoxib."6.70Effect of deracoxib, a new COX-2 inhibitor, on the prevention of lameness induced by chemical synovitis in dogs. ( Buonomo, FC; Millis, DL; Moyers, T; Weigel, JP, 2002)
"To investigate the ability of a proprietary antagonist of E-type prostanoid receptor (EP) 4, grapiprant, and carprofen to attenuate lameness attributable to urate-induced synovitis in dogs."5.30Comparison of two inhibitors of E-type prostanoid receptor four and carprofen in dogs with experimentally induced acute synovitis. ( Budsberg, SC; Kleine, SA; Norton, MM; Sandberg, GS, 2019)
"A randomized, placebo-controlled, four-period cross-over laboratory study involving eight dogs was conducted to confirm the effective analgesic dose of firocoxib, a selective COX-2 inhibitor, in a synovitis model of arthritis."5.13Comparison of the effects of firocoxib, carprofen and vedaprofen in a sodium urate crystal induced synovitis model of arthritis in dogs. ( Hanson, PD; Hazewinkel, HA; Pollmeier, M; Theyse, LF; van den Brom, WE, 2008)
"This positive-control study evaluated the efficacy of firocoxib versus carprofen, deracoxib, and meloxicam for the prevention of pain and inflammation in a urate crystal synovitis model of lameness."5.12Firocoxib efficacy preventing urate-induced synovitis, pain, and inflammation in dogs. ( Drag, M; Hanson, PD; Kunkle, BN; Romano, D, 2007)
"To compare the analgesic and anti-inflammatory effect of single doses of carprofen, etodolac, meloxicam, and butorphanol in dogs with induced acute synovitis (acute pain model) via kinetic gait analysis and orthopedic evaluation and examine measurement of serum C-reactive protein (CRP) concentration as an indicator of treatment efficacy."3.72Effect of carprofen, etodolac, meloxicam, or butorphanol in dogs with induced acute synovitis. ( Borer, LR; Peel, JE; Schawalder, P; Seewald, W; Spreng, DE, 2003)
"Synovitis was induced in 1 stifle joint during each treatment by intra-articular injection of sodium urate (SU)."2.94Comparison of the effects on lameness of orally administered acetaminophen-codeine and carprofen in dogs with experimentally induced synovitis. ( Budsberg, SC; Kleine, SA; Norton, MM; Papich, MG; Sandberg, GS, 2020)
"On the fourth day after initiation of treatment, synovitis was induced via intra-articular injection of SU 1 hour before administration of the last treatment dose."2.76Effect of perzinfotel and a proprietary phospholipase A(2) inhibitor on kinetic gait and subjective lameness scores in dogs with sodium urate-induced synovitis. ( Al-Nadaf, S; Budsberg, SC; Cathcart, CJ; Clark, JD; Eppler, CM; Reynolds, LR; Torres, BT; Zwijnenberg, RJ, 2011)
"Carprofen was also somewhat effective in attenuating the severity of urate-induced synovitis but to a lesser degree than the medium dose of deracoxib."2.70Effect of deracoxib, a new COX-2 inhibitor, on the prevention of lameness induced by chemical synovitis in dogs. ( Buonomo, FC; Millis, DL; Moyers, T; Weigel, JP, 2002)
" ML-1,785,713 had high oral bioavailability (101%), low systemic clearance (77 mL/min/kg), and an elimination half-life of 5."1.32In vitro effects and in vivo efficacy of a novel cyclooxygenase-2 inhibitor in dogs with experimentally induced synovitis. ( Andersen, DR; Black, WC; Brideau, C; Hanson, PD; Hickey, GJ; McCann, ME; Zhang, D, 2004)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (62.50)29.6817
2010's2 (25.00)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Budsberg, SC3
Kleine, SA2
Norton, MM2
Sandberg, GS2
Papich, MG1
Torres, BT1
Zwijnenberg, RJ1
Eppler, CM1
Clark, JD1
Cathcart, CJ1
Reynolds, LR1
Al-Nadaf, S1
Millis, DL1
Weigel, JP1
Moyers, T1
Buonomo, FC1
Borer, LR1
Peel, JE1
Seewald, W1
Schawalder, P1
Spreng, DE1
McCann, ME1
Andersen, DR1
Zhang, D1
Brideau, C1
Black, WC1
Hanson, PD3
Hickey, GJ1
Hazewinkel, HA1
van den Brom, WE1
Theyse, LF1
Pollmeier, M1
Drag, M1
Kunkle, BN1
Romano, D1

Trials

6 trials available for carprofen and Synovitis

ArticleYear
Comparison of two inhibitors of E-type prostanoid receptor four and carprofen in dogs with experimentally induced acute synovitis.
    American journal of veterinary research, 2019, Volume: 80, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Cross-Over Studies; Dog Diseases; Dogs

2019
Comparison of the effects on lameness of orally administered acetaminophen-codeine and carprofen in dogs with experimentally induced synovitis.
    American journal of veterinary research, 2020, Volume: 81, Issue:8

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Codeine; Cross-Over Stu

2020
Effect of perzinfotel and a proprietary phospholipase A(2) inhibitor on kinetic gait and subjective lameness scores in dogs with sodium urate-induced synovitis.
    American journal of veterinary research, 2011, Volume: 72, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azabicyclo Compounds; Blood Proteins; Carbazoles;

2011
Effect of deracoxib, a new COX-2 inhibitor, on the prevention of lameness induced by chemical synovitis in dogs.
    Veterinary therapeutics : research in applied veterinary medicine, 2002,Winter, Volume: 3, Issue:4

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Cyclooxygenase I

2002
Comparison of the effects of firocoxib, carprofen and vedaprofen in a sodium urate crystal induced synovitis model of arthritis in dogs.
    Research in veterinary science, 2008, Volume: 84, Issue:1

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Carbazoles; Cross-Over

2008
Firocoxib efficacy preventing urate-induced synovitis, pain, and inflammation in dogs.
    Veterinary therapeutics : research in applied veterinary medicine, 2007,Spring, Volume: 8, Issue:1

    Topics: 4-Butyrolactone; Animals; Carbazoles; Cyclooxygenase 2 Inhibitors; Dog Diseases; Dogs; Female; Lamen

2007

Other Studies

2 other studies available for carprofen and Synovitis

ArticleYear
Effect of carprofen, etodolac, meloxicam, or butorphanol in dogs with induced acute synovitis.
    American journal of veterinary research, 2003, Volume: 64, Issue:11

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butorphanol; Carbazoles; Dog Diseas

2003
In vitro effects and in vivo efficacy of a novel cyclooxygenase-2 inhibitor in dogs with experimentally induced synovitis.
    American journal of veterinary research, 2004, Volume: 65, Issue:4

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Cyclooxygenase Inhibi

2004