carprofen has been researched along with Synovitis in 8 studies
carprofen: RN given refers to cpd without isomeric designation
carprofen : Propanoic acid in which one of the methylene hydrogens is substituted by a 6-chloro-9H-carbazol-2-yl group. A non-steroidal anti-inflammatory drug, it is no longer used in human medicine but is still used for treatment of arthritis in elderly dogs.
Synovitis: Inflammation of the SYNOVIAL MEMBRANE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the ability of a proprietary antagonist of E-type prostanoid receptor (EP) 4, grapiprant, and carprofen to attenuate lameness attributable to urate-induced synovitis in dogs." | 9.30 | Comparison of two inhibitors of E-type prostanoid receptor four and carprofen in dogs with experimentally induced acute synovitis. ( Budsberg, SC; Kleine, SA; Norton, MM; Sandberg, GS, 2019) |
| "A randomized, placebo-controlled, four-period cross-over laboratory study involving eight dogs was conducted to confirm the effective analgesic dose of firocoxib, a selective COX-2 inhibitor, in a synovitis model of arthritis." | 9.13 | Comparison of the effects of firocoxib, carprofen and vedaprofen in a sodium urate crystal induced synovitis model of arthritis in dogs. ( Hanson, PD; Hazewinkel, HA; Pollmeier, M; Theyse, LF; van den Brom, WE, 2008) |
| "This positive-control study evaluated the efficacy of firocoxib versus carprofen, deracoxib, and meloxicam for the prevention of pain and inflammation in a urate crystal synovitis model of lameness." | 9.12 | Firocoxib efficacy preventing urate-induced synovitis, pain, and inflammation in dogs. ( Drag, M; Hanson, PD; Kunkle, BN; Romano, D, 2007) |
| "To compare the analgesic and anti-inflammatory effect of single doses of carprofen, etodolac, meloxicam, and butorphanol in dogs with induced acute synovitis (acute pain model) via kinetic gait analysis and orthopedic evaluation and examine measurement of serum C-reactive protein (CRP) concentration as an indicator of treatment efficacy." | 7.72 | Effect of carprofen, etodolac, meloxicam, or butorphanol in dogs with induced acute synovitis. ( Borer, LR; Peel, JE; Schawalder, P; Seewald, W; Spreng, DE, 2003) |
| "Synovitis was induced in 1 stifle joint during each treatment by intra-articular injection of sodium urate (SU)." | 6.94 | Comparison of the effects on lameness of orally administered acetaminophen-codeine and carprofen in dogs with experimentally induced synovitis. ( Budsberg, SC; Kleine, SA; Norton, MM; Papich, MG; Sandberg, GS, 2020) |
| "Carprofen was also somewhat effective in attenuating the severity of urate-induced synovitis but to a lesser degree than the medium dose of deracoxib." | 6.70 | Effect of deracoxib, a new COX-2 inhibitor, on the prevention of lameness induced by chemical synovitis in dogs. ( Buonomo, FC; Millis, DL; Moyers, T; Weigel, JP, 2002) |
| "To investigate the ability of a proprietary antagonist of E-type prostanoid receptor (EP) 4, grapiprant, and carprofen to attenuate lameness attributable to urate-induced synovitis in dogs." | 5.30 | Comparison of two inhibitors of E-type prostanoid receptor four and carprofen in dogs with experimentally induced acute synovitis. ( Budsberg, SC; Kleine, SA; Norton, MM; Sandberg, GS, 2019) |
| "A randomized, placebo-controlled, four-period cross-over laboratory study involving eight dogs was conducted to confirm the effective analgesic dose of firocoxib, a selective COX-2 inhibitor, in a synovitis model of arthritis." | 5.13 | Comparison of the effects of firocoxib, carprofen and vedaprofen in a sodium urate crystal induced synovitis model of arthritis in dogs. ( Hanson, PD; Hazewinkel, HA; Pollmeier, M; Theyse, LF; van den Brom, WE, 2008) |
| "This positive-control study evaluated the efficacy of firocoxib versus carprofen, deracoxib, and meloxicam for the prevention of pain and inflammation in a urate crystal synovitis model of lameness." | 5.12 | Firocoxib efficacy preventing urate-induced synovitis, pain, and inflammation in dogs. ( Drag, M; Hanson, PD; Kunkle, BN; Romano, D, 2007) |
| "To compare the analgesic and anti-inflammatory effect of single doses of carprofen, etodolac, meloxicam, and butorphanol in dogs with induced acute synovitis (acute pain model) via kinetic gait analysis and orthopedic evaluation and examine measurement of serum C-reactive protein (CRP) concentration as an indicator of treatment efficacy." | 3.72 | Effect of carprofen, etodolac, meloxicam, or butorphanol in dogs with induced acute synovitis. ( Borer, LR; Peel, JE; Schawalder, P; Seewald, W; Spreng, DE, 2003) |
| "Synovitis was induced in 1 stifle joint during each treatment by intra-articular injection of sodium urate (SU)." | 2.94 | Comparison of the effects on lameness of orally administered acetaminophen-codeine and carprofen in dogs with experimentally induced synovitis. ( Budsberg, SC; Kleine, SA; Norton, MM; Papich, MG; Sandberg, GS, 2020) |
| "On the fourth day after initiation of treatment, synovitis was induced via intra-articular injection of SU 1 hour before administration of the last treatment dose." | 2.76 | Effect of perzinfotel and a proprietary phospholipase A(2) inhibitor on kinetic gait and subjective lameness scores in dogs with sodium urate-induced synovitis. ( Al-Nadaf, S; Budsberg, SC; Cathcart, CJ; Clark, JD; Eppler, CM; Reynolds, LR; Torres, BT; Zwijnenberg, RJ, 2011) |
| "Carprofen was also somewhat effective in attenuating the severity of urate-induced synovitis but to a lesser degree than the medium dose of deracoxib." | 2.70 | Effect of deracoxib, a new COX-2 inhibitor, on the prevention of lameness induced by chemical synovitis in dogs. ( Buonomo, FC; Millis, DL; Moyers, T; Weigel, JP, 2002) |
| " ML-1,785,713 had high oral bioavailability (101%), low systemic clearance (77 mL/min/kg), and an elimination half-life of 5." | 1.32 | In vitro effects and in vivo efficacy of a novel cyclooxygenase-2 inhibitor in dogs with experimentally induced synovitis. ( Andersen, DR; Black, WC; Brideau, C; Hanson, PD; Hickey, GJ; McCann, ME; Zhang, D, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Budsberg, SC | 3 |
| Kleine, SA | 2 |
| Norton, MM | 2 |
| Sandberg, GS | 2 |
| Papich, MG | 1 |
| Torres, BT | 1 |
| Zwijnenberg, RJ | 1 |
| Eppler, CM | 1 |
| Clark, JD | 1 |
| Cathcart, CJ | 1 |
| Reynolds, LR | 1 |
| Al-Nadaf, S | 1 |
| Millis, DL | 1 |
| Weigel, JP | 1 |
| Moyers, T | 1 |
| Buonomo, FC | 1 |
| Borer, LR | 1 |
| Peel, JE | 1 |
| Seewald, W | 1 |
| Schawalder, P | 1 |
| Spreng, DE | 1 |
| McCann, ME | 1 |
| Andersen, DR | 1 |
| Zhang, D | 1 |
| Brideau, C | 1 |
| Black, WC | 1 |
| Hanson, PD | 3 |
| Hickey, GJ | 1 |
| Hazewinkel, HA | 1 |
| van den Brom, WE | 1 |
| Theyse, LF | 1 |
| Pollmeier, M | 1 |
| Drag, M | 1 |
| Kunkle, BN | 1 |
| Romano, D | 1 |
6 trials available for carprofen and Synovitis
| Article | Year |
|---|---|
Comparison of two inhibitors of E-type prostanoid receptor four and carprofen in dogs with experimentally induced acute synovitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Cross-Over Studies; Dog Diseases; Dogs | 2019 |
Comparison of the effects on lameness of orally administered acetaminophen-codeine and carprofen in dogs with experimentally induced synovitis.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Codeine; Cross-Over Stu | 2020 |
Effect of perzinfotel and a proprietary phospholipase A(2) inhibitor on kinetic gait and subjective lameness scores in dogs with sodium urate-induced synovitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azabicyclo Compounds; Blood Proteins; Carbazoles; | 2011 |
Effect of deracoxib, a new COX-2 inhibitor, on the prevention of lameness induced by chemical synovitis in dogs.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Cyclooxygenase I | 2002 |
Comparison of the effects of firocoxib, carprofen and vedaprofen in a sodium urate crystal induced synovitis model of arthritis in dogs.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Carbazoles; Cross-Over | 2008 |
Firocoxib efficacy preventing urate-induced synovitis, pain, and inflammation in dogs.
Topics: 4-Butyrolactone; Animals; Carbazoles; Cyclooxygenase 2 Inhibitors; Dog Diseases; Dogs; Female; Lamen | 2007 |
2 other studies available for carprofen and Synovitis
| Article | Year |
|---|---|
Effect of carprofen, etodolac, meloxicam, or butorphanol in dogs with induced acute synovitis.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butorphanol; Carbazoles; Dog Diseas | 2003 |
In vitro effects and in vivo efficacy of a novel cyclooxygenase-2 inhibitor in dogs with experimentally induced synovitis.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Cyclooxygenase Inhibi | 2004 |