carprofen has been researched along with Disease Models, Animal in 22 studies
carprofen: RN given refers to cpd without isomeric designation
carprofen : Propanoic acid in which one of the methylene hydrogens is substituted by a 6-chloro-9H-carbazol-2-yl group. A non-steroidal anti-inflammatory drug, it is no longer used in human medicine but is still used for treatment of arthritis in elderly dogs.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the efficacy and bioavailability of non-steroidal anti-inflammatory drugs (NSAIDs) when administered orally to sheep." | 6.80 | Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep. ( Colditz, IG; Hinch, G; Lee, C; Marini, D; Petherick, JC; Pippia, J, 2015) |
| "Carprofen treatment decreased the width of osteophytes (p < 0." | 5.31 | Carprofen simultaneously reduces progression of morphological changes in cartilage and subchondral bone in experimental dog osteoarthritis. ( Fernandes, JC; Hilal, G; Jolicoeur, FC; Jovanovic, DV; Lajeunesse, D; Lascau-Coman, V; Martel-Pelletier, J; Pelletier, JP, 2000) |
| "The authors examined the potential of the cyclooxygenase 2 (COX-2) inhibitor carprofen to reproducibly induce anastomotic leakage." | 3.79 | Perioperative pain relief by a COX-2 inhibitor affects ileal repair and provides a model for anastomotic leakage in the intestine. ( de Man, BM; Hendriks, T; Lomme, RM; van der Vijver, RJ; van Laarhoven, CJ, 2013) |
| " We wished to establish whether a behaviour-based approach, originally developed to assess postoperative pain, could be used to determine positive effects of the analgesics carprofen and meloxicam in rats that might be experiencing pain during tumour development in an orthotopic model of bladder cancer." | 3.72 | Behavioural assessment of the effects of tumour growth in rats and the influence of the analgesics carprofen and meloxicam. ( Davies, BR; Flecknell, PA; Roughan, JV, 2004) |
| "To determine the efficacy and bioavailability of non-steroidal anti-inflammatory drugs (NSAIDs) when administered orally to sheep." | 2.80 | Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep. ( Colditz, IG; Hinch, G; Lee, C; Marini, D; Petherick, JC; Pippia, J, 2015) |
| "These results suggest that hyperalgesia induced by a tourniquet may be a useful technique for the investigation of the anti-nociceptive effects of analgesic drugs in sheep." | 2.67 | Effects of non-steroidal anti-inflammatory drugs on the hyperalgesia to noxious mechanical stimulation induced by the application of a tourniquet to a forelimb of sheep. ( Nolan, AM; Welsh, EM, 1994) |
| "Buprenorphine treatment reduced facial pain expression scores, improved mobility, stance and lameness scores and it did not supress the CFA-induced ankle swelling, contrary to carprofen." | 1.72 | Effects of buprenorphine on model development in an adjuvant-induced monoarthritis rat model. ( Abelson, KSP; Berke, MS; Fensholdt, LKD; Hestehave, S; Kalliokoski, O, 2022) |
| "Acute postoperative pain remains a significant healthcare issue." | 1.43 | Characterization of the Affective Component of Acute Postoperative Pain Associated with a Novel Rat Model of Inguinal Hernia Repair Pain. ( Bree, D; Broom, DC; Finn, DP; Kelly, JP; Moriarty, O; Roche, M, 2016) |
| "Acute pain following inguinal hernia repair can be difficult to treat." | 1.42 | Development and characterization of a novel, anatomically relevant rat model of acute postoperative pain. ( Bannerton, K; Bree, D; Broom, DC; Finn, DP; Kelly, JP; Moriarty, O; Morris, B; O'Mahony, CM; Roche, M, 2015) |
| "Carprofen alone was more effective at the second hour post-surgery when signs of pain reduced to 74±24 from 113±40 in the first hour (p<0." | 1.40 | Rat experimental model of myocardial ischemia/reperfusion injury: an ethical approach to set up the analgesic management of acute post-surgical pain. ( Calvillo, L; Casana, R; Ciuffreda, MC; Gnecchi, M; Roughan, J; Spazzolini, C; Tolva, V; Vanoli, E, 2014) |
| "Because inflammation is critical to both the development and resolution of VT, analgesic medications have the potential to adversely affect multiple parameters of interest in VT research." | 1.40 | Effects of analgesic use on inflammation and hematology in a murine model of venous thrombosis. ( Diaz, JA; Hawley, AE; Hish, GA; Lester, PA; Myers, DD, 2014) |
| "Treatment with carprofen is consistently associated with better functional outcome." | 1.38 | The anti-inflammatory drug carprofen improves long-term outcome and induces gliogenesis after traumatic brain injury. ( Alexandrovich, AG; Leker, RR; Shohami, E; Thau-Zuchman, O; Trembovler, V, 2012) |
| "Carprofen treatment decreased the width of osteophytes (p < 0." | 1.31 | Carprofen simultaneously reduces progression of morphological changes in cartilage and subchondral bone in experimental dog osteoarthritis. ( Fernandes, JC; Hilal, G; Jolicoeur, FC; Jovanovic, DV; Lajeunesse, D; Lascau-Coman, V; Martel-Pelletier, J; Pelletier, JP, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 14 (63.64) | 24.3611 |
| 2020's | 3 (13.64) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Berke, MS | 1 |
| Fensholdt, LKD | 1 |
| Hestehave, S | 1 |
| Kalliokoski, O | 1 |
| Abelson, KSP | 1 |
| Lee, D | 1 |
| Ryoo, JE | 1 |
| Hong, S | 1 |
| Kim, HY | 1 |
| Kim, Y | 1 |
| Redaelli, V | 1 |
| Papa, S | 1 |
| Marsella, G | 1 |
| Grignaschi, G | 1 |
| Bosi, A | 1 |
| Ludwig, N | 1 |
| Luzi, F | 1 |
| Vismara, I | 1 |
| Rimondo, S | 1 |
| Veglianese, P | 1 |
| Tepteva, S | 1 |
| Mazzola, S | 1 |
| Zerbi, P | 1 |
| Porcu, L | 1 |
| Roughan, JV | 3 |
| Parati, G | 1 |
| Calvillo, L | 2 |
| Smeester, BA | 1 |
| Lee, JH | 1 |
| Beitz, AJ | 1 |
| Shepherd, AJ | 1 |
| Mohapatra, DP | 1 |
| Ellwardt, E | 1 |
| Pramanik, G | 1 |
| Luchtman, D | 1 |
| Novkovic, T | 1 |
| Jubal, ER | 1 |
| Vogt, J | 1 |
| Arnoux, I | 1 |
| Vogelaar, CF | 1 |
| Mandal, S | 1 |
| Schmalz, M | 1 |
| Barger, Z | 1 |
| Ruiz de Azua, I | 1 |
| Kuhlmann, T | 1 |
| Lutz, B | 1 |
| Mittmann, T | 1 |
| Bittner, S | 1 |
| Zipp, F | 1 |
| Stroh, A | 1 |
| Krishnan, V | 1 |
| Booker, D | 1 |
| Cunningham, G | 1 |
| Jadapalli, JK | 1 |
| Kain, V | 1 |
| Pullen, AB | 1 |
| Halade, GV | 1 |
| Poulet, B | 1 |
| de Souza, R | 1 |
| Knights, CB | 1 |
| Gentry, C | 1 |
| Wilson, AM | 1 |
| Bevan, S | 1 |
| Chang, YM | 1 |
| Pitsillides, AA | 1 |
| Ciuffreda, MC | 1 |
| Tolva, V | 1 |
| Casana, R | 1 |
| Gnecchi, M | 1 |
| Vanoli, E | 1 |
| Spazzolini, C | 1 |
| Roughan, J | 1 |
| Hish, GA | 1 |
| Diaz, JA | 1 |
| Hawley, AE | 1 |
| Myers, DD | 1 |
| Lester, PA | 1 |
| Bree, D | 2 |
| Moriarty, O | 2 |
| O'Mahony, CM | 1 |
| Morris, B | 1 |
| Bannerton, K | 1 |
| Broom, DC | 2 |
| Kelly, JP | 2 |
| Roche, M | 2 |
| Finn, DP | 2 |
| Marini, D | 1 |
| Pippia, J | 1 |
| Colditz, IG | 1 |
| Hinch, G | 1 |
| Petherick, JC | 1 |
| Lee, C | 1 |
| Thau-Zuchman, O | 1 |
| Shohami, E | 1 |
| Alexandrovich, AG | 1 |
| Trembovler, V | 1 |
| Leker, RR | 1 |
| van der Vijver, RJ | 1 |
| van Laarhoven, CJ | 1 |
| de Man, BM | 1 |
| Lomme, RM | 1 |
| Hendriks, T | 1 |
| Teixeira, FM | 1 |
| Castro, LL | 1 |
| Ferreira, RT | 1 |
| Pires, PA | 1 |
| Vanderlinde, FA | 1 |
| Medeiros, MA | 1 |
| Flecknell, PA | 2 |
| Davies, BR | 1 |
| Bingham, D | 1 |
| Macrae, IM | 1 |
| Carswell, HV | 1 |
| Welsh, EM | 1 |
| Nolan, AM | 1 |
| Pelletier, JP | 1 |
| Lajeunesse, D | 1 |
| Jovanovic, DV | 1 |
| Lascau-Coman, V | 1 |
| Jolicoeur, FC | 1 |
| Hilal, G | 1 |
| Fernandes, JC | 1 |
| Martel-Pelletier, J | 1 |
2 trials available for carprofen and Disease Models, Animal
| Article | Year |
|---|---|
Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Car | 2015 |
Effects of non-steroidal anti-inflammatory drugs on the hyperalgesia to noxious mechanical stimulation induced by the application of a tourniquet to a forelimb of sheep.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Clonixin; Cross-Over Studies; Disease | 1994 |
20 other studies available for carprofen and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Effects of buprenorphine on model development in an adjuvant-induced monoarthritis rat model.
Topics: Analgesics, Opioid; Animals; Ankle Joint; Arthritis, Experimental; Behavior, Animal; Body Weight; Bu | 2022 |
Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Carbazoles; Disease Models, Animal; Memory Disord | 2023 |
A refinement approach in a mouse model of rehabilitation research. Analgesia strategy, reduction approach and infrared thermography in spinal cord injury.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Buprenorphine; Car | 2019 |
Influence of social interaction on nociceptive-induced changes in locomotor activity in a mouse model of acute inflammatory pain: Use of novel thermal assays.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Disease Models, Animal; Freund's Adjuv | 2017 |
Pharmacological validation of voluntary gait and mechanical sensitivity assays associated with inflammatory and neuropathic pain in mice.
Topics: Analgesics; Animals; Buprenorphine; Carbazoles; Disease Models, Animal; Female; Freund's Adjuvant; G | 2018 |
Maladaptive cortical hyperactivity upon recovery from experimental autoimmune encephalomyelitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Cells, Cultured; Cerebral Cortex; Cupr | 2018 |
Pretreatment of carprofen impaired initiation of inflammatory- and overlapping resolution response and promoted cardiorenal syndrome in heart failure.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Carbazoles; Cardio-Renal Syndrome; Cyt | 2019 |
Modifications of gait as predictors of natural osteoarthritis progression in STR/Ort mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Carbazoles; Disease Models, Animal; Di | 2014 |
Rat experimental model of myocardial ischemia/reperfusion injury: an ethical approach to set up the analgesic management of acute post-surgical pain.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Disease Models, An | 2014 |
Effects of analgesic use on inflammation and hematology in a murine model of venous thrombosis.
Topics: Analgesics; Anesthetics, Local; Animals; Bupivacaine; Buprenorphine; Carbazoles; Disease Models, Ani | 2014 |
Development and characterization of a novel, anatomically relevant rat model of acute postoperative pain.
Topics: Acetaminophen; Acute Pain; Analgesics; Animals; Behavior, Animal; Carbazoles; Disease Models, Animal | 2015 |
Characterization of the Affective Component of Acute Postoperative Pain Associated with a Novel Rat Model of Inguinal Hernia Repair Pain.
Topics: Acute Pain; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Disease Models, Animal; He | 2016 |
The anti-inflammatory drug carprofen improves long-term outcome and induces gliogenesis after traumatic brain injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Injuries; Carbazoles; Cell Proliferation; Di | 2012 |
Perioperative pain relief by a COX-2 inhibitor affects ileal repair and provides a model for anastomotic leakage in the intestine.
Topics: Analgesics, Opioid; Anastomotic Leak; Animals; Buprenorphine; Carbazoles; Collagen; Cyclooxygenase 2 | 2013 |
High-frequency electroacupuncture versus carprofen in an incisional pain model in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Disease Models, Animal; Electroacupunc | 2012 |
Evaluation of a short duration behaviour-based post-operative pain scoring system in rats.
Topics: Abdominal Pain; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior | 2003 |
Behavioural assessment of the effects of tumour growth in rats and the influence of the analgesics carprofen and meloxicam.
Topics: Analysis of Variance; Animals; Behavior, Animal; Carbazoles; Disease Models, Animal; Male; Meloxicam | 2004 |
Detrimental effects of 17beta-oestradiol after permanent middle cerebral artery occlusion.
Topics: Amyloid beta-Protein Precursor; Animals; Axons; Carbazoles; Disease Models, Animal; Dose-Response Re | 2005 |
Carprofen simultaneously reduces progression of morphological changes in cartilage and subchondral bone in experimental dog osteoarthritis.
Topics: Alkaline Phosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone and Bones; Carbazoles; | 2000 |