carprofen has been researched along with Alzheimer Disease in 5 studies
carprofen: RN given refers to cpd without isomeric designation
carprofen : Propanoic acid in which one of the methylene hydrogens is substituted by a 6-chloro-9H-carbazol-2-yl group. A non-steroidal anti-inflammatory drug, it is no longer used in human medicine but is still used for treatment of arthritis in elderly dogs.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Narlawar, R | 1 |
| Pérez Revuelta, BI | 1 |
| Haass, C | 1 |
| Steiner, H | 1 |
| Schmidt, B | 3 |
| Baumann, K | 2 |
| Oehlrich, D | 1 |
| Berthelot, DJ | 1 |
| Gijsen, HJ | 1 |
| Lee, D | 1 |
| Ryoo, JE | 1 |
| Hong, S | 1 |
| Kim, HY | 1 |
| Kim, Y | 1 |
| Salnikov, E | 1 |
| Drung, B | 1 |
| Fabre, G | 1 |
| Itkin, A | 1 |
| Otyepka, M | 1 |
| Dencher, NA | 1 |
| Hauß, T | 1 |
| Trouillas, P | 1 |
| Bechinger, B | 1 |
| Baumann, S | 1 |
| Höttecke, N | 1 |
| Schubenel, R | 1 |
1 review available for carprofen and Alzheimer Disease
| Article | Year |
|---|---|
γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs.
Topics: Alzheimer Disease; Amides; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Ant | 2011 |
4 other studies available for carprofen and Alzheimer Disease
| Article | Year |
|---|---|
Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer gamma-secretase modulators.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Anti-Inflammatory Ag | 2006 |
Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Carbazoles; Disease Models, Animal; Memory Disord | 2023 |
Lipid bilayer position and orientation of novel carprofens, modulators of γ-secretase in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Carbazoles; Humans; Lipid Bilayers; Magneti | 2018 |
NSAID-derived gamma-secretase modulators. Part III: Membrane anchoring.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Anti-Inflammatory Ag | 2009 |