carprofen has been researched along with Ache in 31 studies
carprofen: RN given refers to cpd without isomeric designation
carprofen : Propanoic acid in which one of the methylene hydrogens is substituted by a 6-chloro-9H-carbazol-2-yl group. A non-steroidal anti-inflammatory drug, it is no longer used in human medicine but is still used for treatment of arthritis in elderly dogs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A multi-site, masked, randomised parallel group study employing a double dummy treatment design was performed in canine veterinary patients to determine the comparative efficacy and safety of mavacoxib and carprofen in the treatment of pain and inflammation associated with osteoarthritis for a period of 134 days." | 9.20 | Comparative efficacy and safety of mavacoxib and carprofen in the treatment of canine osteoarthritis. ( Becskei, C; Chaudhry, Y; Payne-Johnson, M; Stegemann, MR, 2015) |
| "The CBPI had robust statistical power to evaluate the treatment effect of carprofen in dogs with osteoarthritis when protocol success criteria were predefined as a reduction ≥ 1 in PIS and ≥ 2 in PSS." | 9.17 | Power of treatment success definitions when the Canine Brief Pain Inventory is used to evaluate carprofen treatment for the control of pain and inflammation in dogs with osteoarthritis. ( Bell, M; Brown, DC; Rhodes, L, 2013) |
| "Six medium to large breed dogs with osteoarthritis were treated with 2 mg/kg of racemic carprofen, mixed with their morning feed, daily for 28 days." | 9.10 | Clinical efficacy and pharmacokinetics of carprofen in the treatment of dogs with osteoarthritis. ( AliAbadi, FS; Lees, P; Lipscomb, VJ; Muir, P; Pead, MJ, 2002) |
| " The effects of an orally administered single dose of placebo, acetylsalicyclic acid (ASA) and (d,1)-6-chloro-a-methyl carbazole-2-acetic acid (carprofen) have been evaluated on an experimental pain model by electrical stimulation of dental pulp in man." | 9.05 | Analgesic activity of carprofen on human experimental dental pain. ( Accornero, N; Berardelli, A; Bini, G; Cruccu, G; Manfredi, M, 1982) |
| " Compared with butorphanol treatment, only carprofen and etodolac were associated with significantly lower pain scores." | 7.72 | Effect of carprofen, etodolac, meloxicam, or butorphanol in dogs with induced acute synovitis. ( Borer, LR; Peel, JE; Schawalder, P; Seewald, W; Spreng, DE, 2003) |
| "The three NSAIDs reached inferred therapeutic concentrations in blood at 2 h after oral administration." | 6.80 | Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep. ( Colditz, IG; Hinch, G; Lee, C; Marini, D; Petherick, JC; Pippia, J, 2015) |
| "After saline, hyperalgesia was detected from 2-6 h, 22-26 h, and at 30 and 36 h." | 6.73 | Carprofen and buprenorphine prevent hyperalgesia in a model of inflammatory pain in cats. ( Dixon, MJ; Ferreira, TH; Luna, SP; Steagall, PV; Taylor, PM, 2007) |
| "Carprofen was also somewhat effective in attenuating the severity of urate-induced synovitis but to a lesser degree than the medium dose of deracoxib." | 6.70 | Effect of deracoxib, a new COX-2 inhibitor, on the prevention of lameness induced by chemical synovitis in dogs. ( Buonomo, FC; Millis, DL; Moyers, T; Weigel, JP, 2002) |
| "Carprofen is a propionic acid-derived NSAID that has anti-inflammatory, analgesic, and antipyretic activity." | 6.40 | Use of carprofen for the treatment of pain and inflammation in dogs. ( Fox, SM; Johnston, SA, 1997) |
| "A multi-site, masked, randomised parallel group study employing a double dummy treatment design was performed in canine veterinary patients to determine the comparative efficacy and safety of mavacoxib and carprofen in the treatment of pain and inflammation associated with osteoarthritis for a period of 134 days." | 5.20 | Comparative efficacy and safety of mavacoxib and carprofen in the treatment of canine osteoarthritis. ( Becskei, C; Chaudhry, Y; Payne-Johnson, M; Stegemann, MR, 2015) |
| "The CBPI had robust statistical power to evaluate the treatment effect of carprofen in dogs with osteoarthritis when protocol success criteria were predefined as a reduction ≥ 1 in PIS and ≥ 2 in PSS." | 5.17 | Power of treatment success definitions when the Canine Brief Pain Inventory is used to evaluate carprofen treatment for the control of pain and inflammation in dogs with osteoarthritis. ( Bell, M; Brown, DC; Rhodes, L, 2013) |
| " Our results suggest that analgesic treatment with ABT-116 is not as effective as carprofen or tramadol for treatment of hip arthritis pain in client-owned dogs." | 5.16 | Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritis. ( Bleedorn, JA; Cozzi, EM; Holzman, G; Jacobson, PB; Malek, S; Muir, P; Nemke, B; Sample, SJ; Schaefer, SL; Schwartz, Z, 2012) |
| " In the carprofen and placebo groups, there was poor correlation between the 2 pain evaluation methods (VAS and HCPI items) at the baseline evaluation, but the correlation improved in the carprofen group over time." | 5.15 | Reliability and validity of a visual analogue scale used by owners to measure chronic pain attributable to osteoarthritis in their dogs. ( Hielm-Björkman, AK; Kapatkin, AS; Rita, HJ, 2011) |
| "To determine whether carprofen, a commercially available NSAID, would decrease perceived exertion and signs of pain in dogs and therefore increase muscle mass and hind limb function without decreasing range of motion after lateral fabellar suture stabilization." | 5.15 | Effect of the use of carprofen in dogs undergoing intense rehabilitation after lateral fabellar suture stabilization. ( Dunning, D; Gordon-Evans, WJ; Johnson, AL; Knap, KE, 2011) |
| "The optimum doses of carprofen, flunixin, ketoprofen and sodium salicylate for the treatment of inflammatory pain were determined in domestic fowl using the microcrystalline sodium urate model of articular pain." | 5.11 | Effects of non-steroidal anti-inflammatory drugs on pain-related behaviour in a model of articular pain in the domestic fowl. ( Gentle, MJ; Hocking, PM; Robertson, GW, 2005) |
| "Six medium to large breed dogs with osteoarthritis were treated with 2 mg/kg of racemic carprofen, mixed with their morning feed, daily for 28 days." | 5.10 | Clinical efficacy and pharmacokinetics of carprofen in the treatment of dogs with osteoarthritis. ( AliAbadi, FS; Lees, P; Lipscomb, VJ; Muir, P; Pead, MJ, 2002) |
| " The effects of an orally administered single dose of placebo, acetylsalicyclic acid (ASA) and (d,1)-6-chloro-a-methyl carbazole-2-acetic acid (carprofen) have been evaluated on an experimental pain model by electrical stimulation of dental pulp in man." | 5.05 | Analgesic activity of carprofen on human experimental dental pain. ( Accornero, N; Berardelli, A; Bini, G; Cruccu, G; Manfredi, M, 1982) |
| "The authors examined the potential of the cyclooxygenase 2 (COX-2) inhibitor carprofen to reproducibly induce anastomotic leakage." | 3.79 | Perioperative pain relief by a COX-2 inhibitor affects ileal repair and provides a model for anastomotic leakage in the intestine. ( de Man, BM; Hendriks, T; Lomme, RM; van der Vijver, RJ; van Laarhoven, CJ, 2013) |
| "To determine the effectiveness of a topical anaesthetic formulation (Tri-Solfen) with or without the administration of a non-steroidal anti-inflammatory drug (carprofen) on the pain and distress response associated with ring or surgical castration of ram lambs." | 3.75 | Effects of a topical anaesthetic formulation and systemic carprofen, given singly or in combination, on the cortisol and behavioural responses of Merino lambs to castration. ( Colditz, IG; Fisher, AD; Lee, C; Paull, DR, 2009) |
| "To compare efficacy of flunixin meglumine versus carprofen in controlling pain under field conditions following castration by use of an external clamping technique in calves that received epidural anesthesia." | 3.74 | Effects of nonsteroidal anti-inflammatory drugs on long-term pain in calves castrated by use of an external clamping technique following epidural anesthesia. ( Broom, DM; Lima, MS; Stilwell, G, 2008) |
| "Adult mice were subjected to laparotomy, either combined with pain treatment (carprofen or flunixin, 5 mg/kg s/c bid, for 1 day) or without pain relief." | 3.74 | Assessment of post-laparotomy pain in laboratory mice by telemetric recording of heart rate and heart rate variability. ( Arras, M; Burki, K; Cinelli, P; Kasermann, HP; Rettich, A, 2007) |
| " Compared with butorphanol treatment, only carprofen and etodolac were associated with significantly lower pain scores." | 3.72 | Effect of carprofen, etodolac, meloxicam, or butorphanol in dogs with induced acute synovitis. ( Borer, LR; Peel, JE; Schawalder, P; Seewald, W; Spreng, DE, 2003) |
| " We wished to establish whether a behaviour-based approach, originally developed to assess postoperative pain, could be used to determine positive effects of the analgesics carprofen and meloxicam in rats that might be experiencing pain during tumour development in an orthotopic model of bladder cancer." | 3.72 | Behavioural assessment of the effects of tumour growth in rats and the influence of the analgesics carprofen and meloxicam. ( Davies, BR; Flecknell, PA; Roughan, JV, 2004) |
| "The three NSAIDs reached inferred therapeutic concentrations in blood at 2 h after oral administration." | 2.80 | Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep. ( Colditz, IG; Hinch, G; Lee, C; Marini, D; Petherick, JC; Pippia, J, 2015) |
| "After saline, hyperalgesia was detected from 2-6 h, 22-26 h, and at 30 and 36 h." | 2.73 | Carprofen and buprenorphine prevent hyperalgesia in a model of inflammatory pain in cats. ( Dixon, MJ; Ferreira, TH; Luna, SP; Steagall, PV; Taylor, PM, 2007) |
| "Carprofen was also somewhat effective in attenuating the severity of urate-induced synovitis but to a lesser degree than the medium dose of deracoxib." | 2.70 | Effect of deracoxib, a new COX-2 inhibitor, on the prevention of lameness induced by chemical synovitis in dogs. ( Buonomo, FC; Millis, DL; Moyers, T; Weigel, JP, 2002) |
| "Carprofen is a propionic acid-derived NSAID that has anti-inflammatory, analgesic, and antipyretic activity." | 2.40 | Use of carprofen for the treatment of pain and inflammation in dogs. ( Fox, SM; Johnston, SA, 1997) |
| " Sustained-release (SR) formulations of analgesics maintain plasma levels that should be sufficient to provide sustained analgesia yet require less frequent dosing and thus less handling of and stress to the animals." | 1.40 | Pharmacokinetics of sustained-release analgesics in mice. ( Dorsey, K; Gustafson, DL; Hansen, RJ; Kang, S; Kendall, LV; Lunghofer, PJ, 2014) |
| "Stimuli were stopped if they reached 55 degrees C or 450 mmHg without response." | 1.34 | Effects of buprenorphine, carprofen and saline on thermal and mechanical nociceptive thresholds in cats. ( Brondani, JT; Dixon, MJ; Ferreira, TH; Luna, SP; Steagall, PV; Taylor, PM, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.45) | 18.7374 |
| 1990's | 2 (6.45) | 18.2507 |
| 2000's | 16 (51.61) | 29.6817 |
| 2010's | 11 (35.48) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alves, JC | 1 |
| Santos, AM | 1 |
| Jorge, PI | 1 |
| Brown, DC | 2 |
| Bell, M | 1 |
| Rhodes, L | 1 |
| Kendall, LV | 1 |
| Hansen, RJ | 1 |
| Dorsey, K | 1 |
| Kang, S | 1 |
| Lunghofer, PJ | 1 |
| Gustafson, DL | 1 |
| Payne-Johnson, M | 1 |
| Becskei, C | 1 |
| Chaudhry, Y | 1 |
| Stegemann, MR | 1 |
| Bruno, EA | 1 |
| Guthrie, JW | 1 |
| Ellwood, SA | 1 |
| Mellanby, RJ | 1 |
| Clements, DN | 1 |
| Marini, D | 1 |
| Pippia, J | 1 |
| Colditz, IG | 3 |
| Hinch, G | 1 |
| Petherick, JC | 1 |
| Lee, C | 3 |
| Stilwell, G | 2 |
| Lima, MS | 2 |
| Broom, DM | 2 |
| Boston, RC | 1 |
| Coyne, JC | 1 |
| Farrar, JT | 1 |
| Paull, DR | 2 |
| Fisher, AD | 2 |
| Carvalho, RC | 1 |
| Hielm-Björkman, AK | 1 |
| Kapatkin, AS | 1 |
| Rita, HJ | 1 |
| Gordon-Evans, WJ | 1 |
| Dunning, D | 1 |
| Johnson, AL | 1 |
| Knap, KE | 1 |
| van der Vijver, RJ | 1 |
| van Laarhoven, CJ | 1 |
| de Man, BM | 1 |
| Lomme, RM | 1 |
| Hendriks, T | 1 |
| Malek, S | 1 |
| Sample, SJ | 1 |
| Schwartz, Z | 1 |
| Nemke, B | 1 |
| Jacobson, PB | 1 |
| Cozzi, EM | 1 |
| Schaefer, SL | 1 |
| Bleedorn, JA | 1 |
| Holzman, G | 1 |
| Muir, P | 2 |
| Millis, DL | 1 |
| Weigel, JP | 1 |
| Moyers, T | 1 |
| Buonomo, FC | 1 |
| Borer, LR | 1 |
| Peel, JE | 1 |
| Seewald, W | 1 |
| Schawalder, P | 1 |
| Spreng, DE | 1 |
| Nielsen, AN | 1 |
| Mathiesen, C | 1 |
| Blackburn-Munro, G | 1 |
| Roughan, JV | 1 |
| Flecknell, PA | 1 |
| Davies, BR | 1 |
| Hocking, PM | 1 |
| Robertson, GW | 1 |
| Gentle, MJ | 1 |
| Clark, TP | 1 |
| Atkinson, SJ | 1 |
| Taylor, PM | 2 |
| Steagall, PV | 2 |
| Dixon, MJ | 2 |
| Ferreira, TH | 2 |
| Luna, SP | 2 |
| Brondani, JT | 1 |
| Arras, M | 1 |
| Rettich, A | 1 |
| Cinelli, P | 1 |
| Kasermann, HP | 1 |
| Burki, K | 1 |
| Feldmeier, C | 1 |
| Cruccu, G | 1 |
| Bini, G | 1 |
| Accornero, N | 1 |
| Berardelli, A | 1 |
| Manfredi, M | 1 |
| Fox, SM | 1 |
| Johnston, SA | 1 |
| Danbury, TC | 1 |
| Weeks, CA | 1 |
| Chambers, JP | 1 |
| Waterman-Pearson, AE | 1 |
| Kestin, SC | 1 |
| Price, J | 1 |
| Nolan, AM | 1 |
| Lipscomb, VJ | 1 |
| AliAbadi, FS | 1 |
| Lees, P | 1 |
| Pead, MJ | 1 |
| Schatzmann, U | 1 |
| Gugelmann, M | 1 |
| Von Cranach, J | 1 |
| Ludwig, BM | 1 |
| Rehm, WF | 1 |
2 reviews available for carprofen and Ache
| Article | Year |
|---|---|
The clinical pharmacology of cyclooxygenase-2-selective and dual inhibitors.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Cats; Cyclooxygenase | 2006 |
Use of carprofen for the treatment of pain and inflammation in dogs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1997 |
15 trials available for carprofen and Ache
| Article | Year |
|---|---|
Effect of an Oral Joint Supplement When Compared to Carprofen in the Management of Hip Osteoarthritis in Working Dogs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Chondroitin Sulfates; Dietary Suppleme | 2017 |
Power of treatment success definitions when the Canine Brief Pain Inventory is used to evaluate carprofen treatment for the control of pain and inflammation in dogs with osteoarthritis.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Dog Diseases; Do | 2013 |
Comparative efficacy and safety of mavacoxib and carprofen in the treatment of canine osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Dog Diseases; Dogs; Double-Blind Metho | 2015 |
Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Car | 2015 |
Ability of the canine brief pain inventory to detect response to treatment in dogs with osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Dog Diseases; Dogs; Double-Blind Metho | 2008 |
Reliability and validity of a visual analogue scale used by owners to measure chronic pain attributable to osteoarthritis in their dogs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Chronic Disease; Dog Diseases; Dogs; F | 2011 |
Effect of the use of carprofen in dogs undergoing intense rehabilitation after lateral fabellar suture stabilization.
Topics: Animals; Anterior Cruciate Ligament; Anti-Inflammatory Agents, Non-Steroidal; Biomechanical Phenomen | 2011 |
Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritis.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Carbazoles; | 2012 |
Effect of deracoxib, a new COX-2 inhibitor, on the prevention of lameness induced by chemical synovitis in dogs.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Cyclooxygenase I | 2002 |
Effects of non-steroidal anti-inflammatory drugs on pain-related behaviour in a model of articular pain in the domestic fowl.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Chickens; Clonixin; Dose-Response Rela | 2005 |
Carprofen and buprenorphine prevent hyperalgesia in a model of inflammatory pain in cats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Buprenorphine; Carbazoles; Cat Diseases; Cats; Cro | 2007 |
The analgesic effect of carprofen in acute pain: results of two clinical studies.
Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carbazoles | 1982 |
Analgesic activity of carprofen on human experimental dental pain.
Topics: Adult; Analgesics; Aspirin; Carbazoles; Dental Pulp; Electric Stimulation; Female; Humans; Male; Pai | 1982 |
Analgesia of newborn lambs before castration and tail docking with rubber rings.
Topics: Analgesics, Non-Narcotic; Animals; Animals, Newborn; Behavior, Animal; Carbazoles; Female; Injection | 2001 |
Clinical efficacy and pharmacokinetics of carprofen in the treatment of dogs with osteoarthritis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Breeding; | 2002 |
14 other studies available for carprofen and Ache
| Article | Year |
|---|---|
Pharmacokinetics of sustained-release analgesics in mice.
Topics: Analgesics; Animals; Buprenorphine; Butorphanol; Carbazoles; Delayed-Action Preparations; Female; Me | 2014 |
Global positioning system derived performance measures are responsive indicators of physical activity, disease and the success of clinical treatments in domestic dogs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Dog Diseases; Dogs; Female; Geographic | 2015 |
Effects of nonsteroidal anti-inflammatory drugs on long-term pain in calves castrated by use of an external clamping technique following epidural anesthesia.
Topics: Anesthesia, Epidural; Animal Welfare; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, An | 2008 |
Effects of a topical anaesthetic formulation and systemic carprofen, given singly or in combination, on the cortisol and behavioural responses of Merino lambs to castration.
Topics: Administration, Topical; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Ani | 2009 |
Effects of hot-iron disbudding, using regional anaesthesia with and without carprofen, on cortisol and behaviour of calves.
Topics: Anesthesia, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carbazoles; C | 2012 |
Perioperative pain relief by a COX-2 inhibitor affects ileal repair and provides a model for anastomotic leakage in the intestine.
Topics: Analgesics, Opioid; Anastomotic Leak; Animals; Buprenorphine; Carbazoles; Collagen; Cyclooxygenase 2 | 2013 |
Effect of carprofen, etodolac, meloxicam, or butorphanol in dogs with induced acute synovitis.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butorphanol; Carbazoles; Dog Diseas | 2003 |
Pharmacological characterisation of acid-induced muscle allodynia in rats.
Topics: Acids; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ataxia; Carbazoles; Chr | 2004 |
Behavioural assessment of the effects of tumour growth in rats and the influence of the analgesics carprofen and meloxicam.
Topics: Analysis of Variance; Animals; Behavior, Animal; Carbazoles; Disease Models, Animal; Male; Meloxicam | 2004 |
The effect of a topical anaesthetic formulation, systemic flunixin and carprofen, singly or in combination, on cortisol and behavioural responses of Merino lambs to mulesing.
Topics: Analgesics; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Ca | 2007 |
Effects of buprenorphine, carprofen and saline on thermal and mechanical nociceptive thresholds in cats.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Buprenorphine; Carbazoles; Cat | 2007 |
Assessment of post-laparotomy pain in laboratory mice by telemetric recording of heart rate and heart rate variability.
Topics: Analgesics; Animals; Behavior, Animal; Carbazoles; Clonixin; Heart Rate; Laparotomy; Male; Mice; Mot | 2007 |
Self-selection of the analgesic drug carprofen by lame broiler chickens.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Chickens; Condit | 2000 |
Pharmacodynamic evaluation of the peripheral pain inhibition by carprofen and flunixin in the horse.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Clonixin; Horse Diseases; Horses; Pain | 1990 |